rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline CAS 6649-90-7
| CAS No. | 6649-90-7 |
| Molecular Formula | C12H11Cl3N2 |
| Molecular Weight | 289.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline (CAS 6649-90-7), a certified reference material (molecular formula C12H11Cl3N2, MW 289.59 g/mol) for analytical method development and quality control.
The molecular framework of rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline (C12H11Cl3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11Cl3N2 |
| Molecular Weight | 289.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related rac Standards
- (R)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline (CAS 175779-27-8)
- (S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β-carboline (CAS 175779-28-9)
- 1-(Trichloromethyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-d4 (CAS 1794886-07-9)
- 4-(Trichloromethyl)-6-(trifluoromethyl)-1,3,5-triazin-2-amine (CAS 61082-43-7)
- 4-Phenyl-2-(trichloromethyl)pyrimidine-5-carbaldehyde (CAS 143034-51-9)
- 3-phenyl-5-(trichloromethyl)-1,2,4-oxadiazole (CAS 1208-05-5)
- 2-(Trichloromethyl)-3,4-dihydroquinazolin-4-one (CAS 5558-95-2)
- 3-(Trichloromethyl)quinoxalin-2-ol (CAS 73855-49-9)
Recommended Standards
- 2,2,2-Trichloroethyl 4-(aminomethyl)piperidine-1-carboxylate (CAS 959581-00-1)
- 1-(2-Bromo-1-cyclobutoxyethyl)-3-chlorobenzene (CAS 1249781-04-1)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2,2-difluoroacetohydrazide (CAS 1823183-73-8)
- 1-(2-Bromo-1-(cyclopropylmethoxy)ethyl)-4-chlorobenzene (CAS 1249987-60-7)
- (1-(4-Aminophenyl)azetidin-2-yl)methanol (CAS 344405-84-1)
- 3-Hydroxytetrahydrofuran-2-one (CAS 19444-84-9)
- 3,4',5-Trifluorobenzophenone (CAS 951885-91-9)
- 1-(2-Furylmethyl)-2,4,5-trimethyl-1h-pyrrole-3-carbaldehyde (CAS 1087611-47-9)
- [1,2,4]Triazolo[4,3-a]pyridin-5(1H)-one (CAS 501016-88-2)
- 2-Methoxy-N-(2-methoxybenzyl)ethan-1-amine (CAS 827328-30-3)
- N-(2-Piperidinylmethyl)-N-propyl-1-propanaminedihydrochloride (CAS 1220018-78-9)
- 4-(3-Thienyl)benzenecarbaldehyde (CAS 157730-74-0)
- (2-Chlorothiazol-4-yl)methanamine (CAS 139425-75-5)
- Custom peptides (CAS CATO-CPTD788509)
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