6-chlorofuro[2,3-b]pyridine-2-carboxylic acid CAS 66497-40-3
| CAS No. | 66497-40-3 |
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-chlorofuro[2,3-b]pyridine-2-carboxylic acid (CAS 66497-40-3), molecular formula C8H12ClNO3 and molecular weight 205.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-chlorofuro[2,3-b]pyridine-2-carboxylic acid (C8H12ClNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related chlorofuro Standards
- 2-chlorofuro[2,3-d]pyrimidine-6-carboxylic acid (CAS 1541368-88-0)
- 4-Chlorofuro[2,3-b]quinoline (CAS 111163-82-7)
- 4-chlorofuro[3,2-c]quinoline (CAS 627086-17-3)
- Methyl 5-chlorofuro[2,3-c]pyridine-2-carboxylate, >97% (CAS 1315362-16-3)
- Methyl 7-chlorofuro[2,3-c]pyridine-5-carboxylate (CAS 1824605-51-7)
- 1-(7-Chlorofuro[3,2-b]pyridin-5-yl)ethan-1-ol (CAS 2769929-84-0)
- 4-Chlorofuro[3,2-c]pyridine-7-carboxylic acid (CAS 1256809-80-9)
- 5-Chlorofuro[2,3-c]pyridine-2-carboxylic acid, >97% (CAS 1454285-47-2)
Recommended Standards
- 6-Chloro-8-methylquinoline-2-carbaldehyde (CAS 904886-39-1)
- 6-Chloro-N-(pyridin-2-yl)pyridin-2-amine (CAS 370571-21-4)
- 6-Chloro-5-phenylpyrimidin-4-amine (CAS 3974-20-7)
- 6-Chloro-N-(pyridin-3-yl)pyridin-2-amine (CAS 370571-25-8)
- 6-(1-(Methoxycarbonyl)-5,6,7,8-tetrahydroindolizin-3-yl)benzo[d][1,3]dioxole-5-carboxylic acid (CAS 1448525-06-1)
- 2-(5-methoxy-1,3,4-thiadiazol-2-yl)acetonitrile (CAS 84389-19-5)
- 5-Chloro-8-methyl-2-phenylquinolin-4-ol (CAS 1070879-82-1)
- 3-(5-Methyl-1H-imidazol-1-yl)propanoic acid (CAS 1048920-55-3)
- 2-(3-Methoxyphenyl)-1H-benzo[d]imidazol-5-amine (CAS 263022-16-8)
- N-(3-ethoxybenzyl)-1-(pyridin-3-yl)methanamine (CAS 880804-71-7)
- 1-Acetyl-5-methyl-1H-pyrazole-3-carbonitrile (CAS 60858-37-9)
- 7-benzyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 1244855-70-6)
- 5-Chloro-3-fluoro-2-methylbenzonitrile (CAS 1365969-38-5)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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