4-[3-(Trifluoromethyl)phenyl]piperidine Hydrochloride CAS 6652-16-0
| CAS No. | 6652-16-0 |
| Molecular Formula | C12H14F3N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 265.70 g/mol gives 4-[3-(Trifluoromethyl)phenyl]piperidine Hydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 4-[3-(Trifluoromethyl)phenyl]piperidine Hydrochloride (CAS 6652-16-0), a certified reference material (molecular formula C12H14F3NHCl, MW 265.70 g/mol) for analytical method development and quality control.
The molecular framework of 4-[3-(Trifluoromethyl)phenyl]piperidine Hydrochloride (C12H14F3NHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-[3-(Trifluoromethyl)phenyl]piperidine Hydrochloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H14F3N HCl |
| Molecular Weight | 265.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidin-3-ol hydrochloride (CAS 1000198-74-2)
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidine (CAS 1000198-76-4)
- (2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanol (CAS 1000339-72-9)
- methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate (CAS 1000339-86-5)
- methyl 4-(2-(4-(trifluoromethyl)piperidin-1-yl)ethoxy)benzoate (CAS 1000339-87-6)
- 2-(4-(trifluoromethyl)piperidin-1-yl)thiazole-5-carbaldehyde (CAS 1000339-88-7)
- 3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)benzaldehyde (CAS 1000339-89-8)
- 4-(2-(4-(trifluoromethyl)piperidin-1-yl)acetyl)-1H-pyrrole-2-carbaldehyde (CAS 1000339-90-1)
Recommended Standards
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- tert-Butyl (2-(4-iodophenoxy)ethyl)carbamate (CAS 151978-98-2)
- rac-(1R,2S)-2-(morpholin-4-yl)cyclopropan-1-amine dihydrochloride (CAS 1909287-88-2)
- Hyoscyamine EP Impurity E Trifluoroacetate Salt (CAS 537-29-1（free base）)
- 2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid (CAS 815593-60-3)
- 2-Methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol (CAS 1310707-20-0)
- 1-(3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)ethan-1-one (CAS 478065-94-0)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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