5-Chloro-2-(p-tolyl)-1H-indole CAS 66866-07-7
| CAS No. | 66866-07-7 |
| Molecular Formula | C15H12ClN |
| Molecular Weight | 241.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-2-(p-tolyl)-1H-indole.
5-Chloro-2-(p-tolyl)-1H-indole (CAS 66866-07-7), molecular formula C15H12ClN and molecular weight 241.72 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-2-(p-tolyl)-1H-indole (C15H12ClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-Chloro-2-(p-tolyl)-1H-indole under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12ClN |
| Molecular Weight | 241.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 5-Amino-2-chloro-N-(2-(dimethylamino)ethyl)benzamide (CAS 926247-09-8)
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- 4-Chloro-6-(4-ethylpiperazin-1-yl)pyrimidin-5-amine (CAS 882766-23-6)
- 5-Chloro-3-methyl-1-phenyl-1H-indole (CAS 918163-12-9)
- Europium(III) oxalate hydrate (CAS 304675-55-6)
- Methyl 5-bromobenzo[d]oxazole-2-carboxylate (CAS 954239-61-3)
- (5-Methylbenzo[b]thiophen-3-yl)boronic acid (CAS 1194254-39-1)
- n-Ethyl-2-{[4-(1-hydroxyethyl)phenyl]sulfanyl}-n-methylacetamide (CAS 1378670-93-9)
- 5-Fluoro-2-(methylthio)benzaldehyde (CAS 160503-79-7)
- 1-(3,4,5-Trifluorophenyl)propan-1-ol (CAS 1249316-32-2)
- Ethyl 5,6-Difluoro-1H-indole-2-carboxylate (CAS 169674-34-4)
- 7,8-Dimethyl-11-(4-nitrophenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 338748-17-7)
- 4-([1,1'-Biphenyl]-4-yl)-3-aminobutanoic acid hydrochloride (CAS 1049722-81-7)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
Why CATO?
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