(S)-2-(Methylamino)-3-phenylpropanoic acid hydrochloride CAS 66866-67-9
| CAS No. | 66866-67-9 |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (S)-2-(Methylamino)-3-phenylpropanoic acid hydrochloride (C10H13NO2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
(S)-2-(Methylamino)-3-phenylpropanoic acid hydrochloride (CAS 66866-67-9), molecular formula C10H13NO2HCl and molecular weight 215.68 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13NO2 HCl |
| Molecular Weight | 215.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related S Standards
- 4-(Methylamino)phenyl furan-2-carboxylate (CAS 100063-33-0)
- 2-(methylamino)-6,7-dihydro-3H-purin-6-one (CAS 10030-78-1)
- 6-(Methylamino)pyridine-3-boronic Acid Pinacol Ester (CAS 1005009-98-2)
- 2-(Methylamino)cyclopentan-1-ol (CAS 100524-01-4)
- 2-(Methylamino)ethane-1-thiol (CAS 10061-40-2)
- 1-(2-(Methylamino)-2-oxoethyl)-1H-pyrazole-3-carboxylic acid (CAS 1006463-30-4)
- Ethyl 4-((methylamino)methyl)benzoate hydrochloride (CAS 1007870-76-9)
- 2-methyl-2-(methylamino)-1-phenyl-propan-1-ol (CAS 10079-55-7)
Recommended Standards
- 2-Fluoro-1-morpholinoethanone (CAS 366-38-1)
- 6-Chloro-2-methyl-5-(phenylamino)pyridazin-3(2H)-one (CAS 88804-46-0)
- 3-Chlorobutanenitrile (CAS 53778-71-5)
- 24554-43-6 Dibromopalladium--tris(2-methylphenyl)phosphane (1/2) DTXSID40570419 (CAS 24554-43-6)
- Ethyl 3-(1-(p-tolyl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 1370592-91-8)
- 17-Hydroxy-11β-methyl-19-norprogesterone (CAS 25092-42-6)
- 2-Isopropyl-6-methylbenzaldehyde (CAS 54876-90-3)
- 3-(2-Ethoxy-phenoxysulfonyl)-benzoic acid (CAS 380431-09-4)
- N-(1-Oxo-1,3-dihydroisobenzofuran-5-yl)benzamide (CAS 500260-82-2)
- Des-Leu26-Tirzepatide (CAS CATO-CPTD788947)
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