Methyl 2-hydroxy-5-methylnicotinate CAS 66909-32-8
| CAS No. | 66909-32-8 |
| Molecular Formula | C8H9NO3 |
| Molecular Weight | 167.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 2-hydroxy-5-methylnicotinate (CAS 66909-32-8), molecular formula C8H9NO3 and molecular weight 167.16 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 2-hydroxy-5-methylnicotinate (C8H9NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 2-hydroxy-5-methylnicotinate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9NO3 |
| Molecular Weight | 167.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 5-hydroxy-2-methylnicotinate (CAS 1033809-45-8)
- 3-Hydroxy-4-(methylamino)benzoic acid (CAS 1038478-87-3)
- n-Hydroxy-4-methoxybenzamide (CAS 10507-69-4)
- 3-Hydroxy-4-methoxybenzamide (CAS 109737-15-7)
- 2-Hydroxy-2-(6-methylpyridin-2-yl)acetic acid (CAS 115919-14-7)
- 2-Hydroxy-2-(pyridin-2-yl)propanoic acid (CAS 115919-16-9)
- Methyl 5-Hydroxy-3-methylpyridine-2-carboxylate (CAS 1211516-93-6)
- Methyl 5-hydroxy-4-methylpicolinate (CAS 1211530-55-0)
Recommended Standards
- Methyl 2-Amino-6-hydroxybenzoate (CAS 64241-01-6)
- Methyl 2-hydroxy-6-methylisonicotinate (CAS 98491-78-2)
- Methyl 2-Amino-4-hydroxybenzoate (CAS 401568-70-5)
- Methyl 2-Methoxyisonicotinate (CAS 26156-51-4)
- Methyl 2,6-dimethyl-4-nitrobenzoate (CAS 114820-16-5)
- 2-(4-Butoxy-3-chlorophenyl)ethan-1-amine hydrochloride (CAS 56121-92-7)
- 2-(Benzylamino)-4-fluoro-4-methylpentanoic acid (CAS 2166902-39-0)
- (2-(4-Methoxyphenyl)-1,3-dioxane-5,5-diyl)dimethanol (CAS 122788-52-7)
- 3-(Methoxydimethylsilyl)propane-1-thiol (CAS 14857-97-7)
- 3-Isopropoxy-4-(thieno[2,3-d]pyrimidin-4-ylamino)benzamide (CAS 917908-00-0)
- Mepenzolate Bromide (CAS 76-90-4)
- Ethyl 3-cyano-2-oxopropanoate (CAS 56290-86-9)
- (R)-3-Amino-1-(methylsulfonyl)pyrrolidine Hydrochloride (CAS 651056-85-8)
- Allo-D-Ile12-Tirzepatide (CAS CATO-CPTD788963)
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