2-(Chloromethyl)-1-ethyl-1H-benzimidazole CAS 66947-93-1

Purity 95%In StockPharmaceutical Standards
CAS No.66947-93-1
Molecular FormulaC10H11ClN2
Molecular Weight194.66 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Chloromethyl)-1-ethyl-1H-benzimidazole CAS 66947-93-1 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Chloromethyl)-1-ethyl-1H-benzimidazole.

2-(Chloromethyl)-1-ethyl-1H-benzimidazole (CAS 66947-93-1), molecular formula C10H11ClN2 and molecular weight 194.66 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(Chloromethyl)-1-ethyl-1H-benzimidazole (C10H11ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(Chloromethyl)-1-ethyl-1H-benzimidazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H11ClN2
Molecular Weight194.66 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity95%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1976
Halogen ContentCl-containing
Nitrogen Atoms2

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Why CATO?