Methyl 2-chloro-2-(4-chlorophenyl)acetate CAS 67447-60-3
| CAS No. | 67447-60-3 |
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 219.06 g/mol gives Methyl 2-chloro-2-(4-chlorophenyl)acetate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Methyl 2-chloro-2-(4-chlorophenyl)acetate (CAS 67447-60-3), molecular formula C9H8Cl2O2 and molecular weight 219.06 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 2-chloro-2-(4-chlorophenyl)acetate (C9H8Cl2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
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Recommended Standards
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- 4-Benzyloxy-Alpha-cyanocinnamic acid (CAS 162882-36-2)
- (±)-1-Amino-2-propanol-1,1,2,3,3,3-d6 (CAS 1219795-13-7)
- N1,N1-Diethyl-N2-methyl-N2-phenylethane-1,2-diamine (CAS 74474-29-6)
- 6-Chloro-N4-methylpyridine-3,4-diamine (CAS 87034-76-2)
- Tau Peptide (273-284) trifluoroacetate salt (CAS 1663490-91-2)
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