2,2,2-Trifluoroethane-1-sulfonamide CAS 67497-95-4
| CAS No. | 67497-95-4 |
| Molecular Formula | C2H4F3NO2S |
| Molecular Weight | 163.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,2,2-Trifluoroethane-1-sulfonamide (C2H4F3NO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2,2,2-Trifluoroethane-1-sulfonamide (CAS 67497-95-4) is a high-purity analytical reference standard with the molecular formula C2H4F3NO2S and a molecular weight of 163.12 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C2H4F3NO2S |
| Molecular Weight | 163.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoroethane Standards
- Sodium 2,2,2-trifluoroethane-1-sulfinate (CAS 234434-08-3)
- 2,2,2-trifluoroethane-1-sulfinamide (CAS 1803591-85-6)
- 2,2,2-Trifluoroethane-1,1-diol (CAS 421-53-4)
- 1,1,1-Trifluoroethane (Freon #143A) (CAS 420-46-2)
- 4-[(2,2,2-trifluoroethane)sulfonyl]benzoic acid (CAS 1016827-86-3)
- 1,1'-(2,2,2-Trifluoroethane-1,1-diyl)bis(1,3,5-trimethyl-1lambda5-benzene) (CAS 1314534-82-1)
Recommended Standards
- 2-(3-(Difluoromethyl)isoxazol-5-yl)ethan-1-ol (CAS 2092553-86-9)
- 3-(3,5-Difluorophenyl)-2-Propynenitrile (CAS 575433-44-2)
- (1S,4S,5R)-6,6-difluoro-4-(hydroxymethyl)-3-azabicyclo[3.1.0]Hexan-2-one (CAS 2306253-79-0)
- 4-Ethynyl-2,6-difluorobenzonitrile (CAS 2380236-60-0)
- Pentyl 2-(4-methoxyphenyl)-8-methylquinoline-4-carboxylate (CAS 355421-25-9)
- (R,E)-ethyl 2,5-dimethyl-4-(methylamino)hex-2-enoate hydrochloride (CAS 2459946-53-1)
- Perfluoroheptane (CAS 335-57-9)
- 5-Chloro-2-((2,6-dichlorobenzyl)oxy)benzoic acid (CAS 938355-18-1)
- 4-Chloro-5-(4-fluorophenyl)-7-(m-tolyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1228504-12-8)
- 2-[1-(methylamino)cyclopentyl]ethanol (CAS 1199774-93-0)
- 6-(4-Isopropylphenyl)-6-oxohexanoic acid (CAS 898791-37-2)
- methyl 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-3-carboxylate hydrochloride (CAS 1461707-94-7)
- 3-Bromo-2-methylbenzofuran (CAS 58863-48-2)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
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