1-(6-Chloro-3-indolyl)-2,2,2-trifluoroethanone CAS 676477-10-4
| CAS No. | 676477-10-4 |
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(6-Chloro-3-indolyl)-2,2,2-trifluoroethanone (CAS 676477-10-4), molecular formula C10H5ClF3NO and molecular weight 247.60 g/mol, is a CATO reference standard with documented purity and traceability.
1-(6-Chloro-3-indolyl)-2,2,2-trifluoroethanone (C10H5ClF3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-(6-Chloro-3-indolyl)-2,2,2-trifluoroethanone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 8-Chloro-5-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-44-5)
- 8-Chloro-6-(trifluoromethyl)quinolin-4-ol (CAS 1065092-49-0)
- 6-Chloro-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-54-7)
- 5-Chloro-8-(trifluoromethyl)quinolin-4-ol (CAS 1065092-56-9)
- 1-(4-Chloro-1H-indol-3-yl)-2,2,2-trifluoro-ethanone (CAS 1119282-66-4)
- 2-Chloro-6-(5-trifluoromethylpyrazol-1-yl)pyridine (CAS 1150164-45-6)
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Recommended Standards
- 8-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline (CAS 18706-22-4)
- 1-(7-Chloro-3-indolyl)-2,2,2-trifluoroethanone (CAS 934185-80-5)
- 6-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline (CAS 18706-21-3)
- 1-Chloro-6-(trifluoromethoxy)isoquinoline (CAS 630423-44-8)
- 5-(chloromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-1,2,3,4-tetrazole (CAS 1094265-93-6)
- 2-bromopyrimidin-5-amine (CAS 56621-91-1)
- 2-(Acetylthio)ethyl 2,3,4,6-Tetra-O-acetyl-β-D-glucopyranoside (CAS 34044-34-3)
- 2-((4-Cyclopropyl-6-(difluoromethyl)pyrimidin-2-yl)oxy)ethanamine (CAS 1160246-47-8)
- N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide (CAS 1798310-55-0)
- 2-Benzyl-2h-1,2,3,4-tetrazol-5-amine (CAS 31694-91-4)
- 7-(3-Chlorophenyl)thieno[3,2-d]pyrimidin-4-ol (CAS 1031969-45-5)
- (4-Ethoxy-2-methylphenyl)methanamine (CAS 1495703-36-0)
- 7-Bromo-3,4-dihydro-4-oxoquinoline-3-carboxylic acid, 97% (CAS 1116339-54-8)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
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