5-Hydroxy-3,4-dihydroquinazolin-2(1H)-one CAS 676543-34-3
| CAS No. | 676543-34-3 |
| Molecular Formula | C8H8N2O2 |
| Molecular Weight | 164.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Hydroxy-3,4-dihydroquinazolin-2(1H)-one (C8H8N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
5-Hydroxy-3,4-dihydroquinazolin-2(1H)-one (CAS 676543-34-3) is a high-purity analytical reference standard with the molecular formula C8H8N2O2 and a molecular weight of 164.16 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8N2O2 |
| Molecular Weight | 164.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
Related Hydroxy Standards
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Recommended Standards
- 5-Hydroxy-2,3-dihydrobenzofuran-6-carboxaldehyde (CAS 99385-88-3)
- 5-Hydroxy-6-methylbenzofuran-2(3H)-one (CAS 78212-98-3)
- 5-Hydroxy-2-(hydroxymethyl)benzimidazole (CAS 886493-60-3)
- 5-Methoxy-1H-indazol-3-ol (CAS 99719-37-6)
- Copper(II) tetrafluoroborate xhydrate 207121-39-9 (CAS 207121-39-9)
- 6-(2-methylpropoxy)pyrimidin-4-amine (CAS 3549-07-3)
- tert-Butyl 5-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (CAS 1646635-53-1)
- 1,2,3,4,6-Penta-O-pivaloyl-D-mannopyranose (CAS 220017-47-0)
- 3-(Cyclopropylmethoxy)benzoic acid (CAS 1047680-61-4)
- (2-(4-Chlorophenyl)cyclopropyl)methanol (CAS 1278662-50-2)
- Methyl (E)-4-(((2-chloropyridin-3-yl)methylene)amino)-3-fluorobenzoate (CAS 1296225-23-4)
- 2,4,6,7-Tetramethyl-2,3-dihydrobenzofuran-5-ol (CAS 86646-86-8)
- 2-(Propan-2-yl)-4-(trifluoromethyl)furan-3-carboxylic acid (CAS 2091455-01-3)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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