2-Amino-4-chloro-6-nitrophenolHydrochloride CAS 67815-68-3
| CAS No. | 67815-68-3 |
| Molecular Formula | C6H5ClN2O3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Amino-4-chloro-6-nitrophenolHydrochloride (C6H5ClN2O3HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Amino-4-chloro-6-nitrophenolHydrochloride (CAS 67815-68-3) is a high-purity analytical reference standard with the molecular formula C6H5ClN2O3HCl and a molecular weight of 225.03 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-4-chloro-6-nitrophenolHydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5ClN2O3 HCl |
| Molecular Weight | 225.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 3-cyclopropyl-3-methylbutanoic acid (CAS 1021939-05-8)
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- methyl 2-oxo-1H,2H,5H,6H,7H,8H,9H-cyclohepta[b]pyridine-3-carboxylate (CAS 243988-46-7)
- 2,3-Dibromo-1,1-diethoxypropane (CAS 10160-86-8)
- (2s,3As,6ar)-1-[(2r)-2-{[(2r)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid (CAS 1807941-03-2)
- Danusertib (CAS 827318-97-8)
- 3H-Pyrazole-3,5-dicarboxylic acid (CAS 85908-17-4)
- 4-Bromo-7-(trifluoromethoxy)-1H-indole 1774896-71-7 (CAS 1774896-71-7)
- n-Methyl-n-[2-(methylamino)ethyl]methanesulfonamide hydrochloride (CAS 1423032-84-1)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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