Diethyl Difluoromalonate CAS 680-65-9
| CAS No. | 680-65-9 |
| Molecular Formula | C7H10F2O4 |
| Molecular Weight | 196.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Diethyl Difluoromalonate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 196.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Diethyl Difluoromalonate (CAS 680-65-9), molecular formula C7H10F2O4 and molecular weight 196.15 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Diethyl Difluoromalonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H10F2O4 |
| Molecular Weight | 196.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
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Recommended Standards
- 7,8-Difluoronaphthalene-1,3-diol (CAS 2858674-29-8)
- Dimethyl 2,2-difluoropentanedioate (CAS 337-97-3)
- 6,7-difluoro-3-methyl-chromen-4-one (CAS 2847139-12-0)
- Ethyl 4,4-difluoro-2-methoxy-3-oxobutanoate (CAS 840521-79-1)
- Zinc Acetate dihydrate (CAS 5970-45-6)
- 2′-Deoxycytidylyl(3′→5′)-2′-deoxyguanosine ammonium salt (CAS 77710-57-7)
- (S)-Methyl piperidine-2-carboxylate (CAS 90710-04-6)
- 1-(Cyclopropylmethyl)-1h-1,2,3-benzotriazole-5-carboxylic acid (CAS 691363-38-9)
- Policresulen Impurity 13 (CAS CATO-C4X-198013)
- 3-(3-Methylphenyl)-3-trifluoromethylpropiophenone (CAS 898791-05-4)
- 2,5,6-Trifluoropyrimidin-4-amine (CAS 25935-33-5)
- 4-(2-Morpholinoethoxy)benzonitrile (CAS 34334-04-8)
- Tert-butyl 2-(azepan-4-yl)acetate hydrochloride (CAS 1864053-29-1)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
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