8-Chloro-2-methylquinolin-4-amine CAS 68017-48-1
| CAS No. | 68017-48-1 |
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8-Chloro-2-methylquinolin-4-amine.
CATO supplies 8-Chloro-2-methylquinolin-4-amine (CAS 68017-48-1), a certified reference material (molecular formula C10H9ClN2, MW 192.64 g/mol) for analytical method development and quality control.
The molecular framework of 8-Chloro-2-methylquinolin-4-amine (C10H9ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Chloro-2-methylquinolin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-chloro-2-cyclopropyl-1H-Pyrrolo[2,3-b]pyridine (CAS 1014613-52-5)
- 7-Chloro-2-methylquinolin-8-amine (CAS 102876-99-3)
- 5-Chloro-2-methylquinolin-8-amine (CAS 102879-01-6)
- 1-Chloro-4-methoxynaphthalene (CAS 10443-43-3)
- 3-Chloro-4-(1H-pyrrol-1-yl)aniline (CAS 106981-50-4)
- 6-Chloro-3-(prop-1-en-2-yl)imidazo[1,2-a]pyridine (CAS 1080429-96-4)
- 2-chloro-5,7-dimethyl-1,6-naphthyridine (CAS 1085267-44-2)
- 1-Chloro-6-methylisoquinolin-5-amine (CAS 1093101-44-0)
Recommended Standards
- 7-Chloro-N-methylquinolin-4-amine (CAS 21875-67-2)
- 8-Chloro-2-methyl-quinolin-5-ylamine (CAS 64485-40-1)
- 7-Chloro-3-methylisoquinolin-5-amine (CAS 608515-69-1)
- 8-Chloro-6-methylquinolin-4-amine (CAS 948293-57-0)
- (S)-N-(3-Pyrrolidinyl)-4-quinazolinamine (CAS 1389310-32-0)
- 2-Phenethylpyridine 1-oxide (CAS 1208-56-6)
- 1,1'-(5-Nitro-2,3-dihydrobenzofuran-2,2-diyl)diethanone (CAS 109831-23-4)
- 2-Methylenecyclohexan-1-ol (CAS 4065-80-9)
- (Propargyloxy)trimethylsilane, 97% (CAS 5582-62-7)
- syn-4-Nitrobenzaldoxime [Deprotecting Agent] (CAS 3717-20-2)
- Sodium 2-(2-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy)acetamido)-5-chlorobenzoate (CAS 1103926-82-4)
- 3-Amino-4-hydroxyquinolin-2(1H)-one hydrochloride (CAS 62175-55-7)
- Methyl 2-amino-2-(2,3-dihydro-1H-inden-2-yl)acetate hydrochloride (CAS 155172-72-8)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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