3-chloro-5-(2-chlorophenyl)isothiazole-4-carboxamide CAS 680212-80-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-chloro-5-(2-chlorophenyl)isothiazole-4-carboxamide.

3-chloro-5-(2-chlorophenyl)isothiazole-4-carboxamide (CAS 680212-80-0) is a high-purity analytical reference standard with the molecular formula C10H6Cl2N2OS and a molecular weight of 273.14 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, 3-chloro-5-(2-chlorophenyl)isothiazole-4-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 273.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-chloro-5-(2-chlorophenyl)isothiazole-4-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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