4-Chloro-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine CAS 681260-56-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine.

4-Chloro-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine (CAS 681260-56-0) is a high-purity analytical reference standard with the molecular formula C12H6ClFN2S and a molecular weight of 264.71 g/mol.

4-Chloro-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine (C12H6ClFN2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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