4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol CAS 681482-81-5

Purity 97%+In StockPharmaceutical Standards
CAS No.681482-81-5
Molecular FormulaC18H18F3NO3
Molecular Weight353.34 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol CAS 681482-81-5 chemical structure

Description

CATO manufactures 4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol (CAS 681482-81-5), molecular formula C18H18F3NO3 and molecular weight 353.34 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4-(4-(4-(Trifluoromethoxy)phenoxy)piperidin-1-yl)phenol (C18H18F3NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

Physical & Chemical Properties

Molecular FormulaC18H18F3NO3
Molecular Weight353.34 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF-containing
Nitrogen Atoms1

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