(3,5-Dibromo-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone CAS 68287-77-4
| CAS No. | 68287-77-4 |
| Molecular Formula | C16H10Br2N2O2 |
| Molecular Weight | 422.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3,5-Dibromo-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone.
CATO supplies (3,5-Dibromo-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone (CAS 68287-77-4), a certified reference material (molecular formula C16H10Br2N2O2, MW 422.07 g/mol) for analytical method development and quality control.
The molecular framework of (3,5-Dibromo-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone (C16H10Br2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H10Br2N2O2 |
| Molecular Weight | 422.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- tert-Butyl 6-bromo-3-iodo-1h-indole-1-carboxylate (CAS 873198-57-3)
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- 4-(4-Methoxyphenyl)-2,4,5,6-tetrahydropyrrolo[2,3-c]pyrazol-3-ol (CAS 1707585-66-7)
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- 6-Fluoro-7-methoxy-3,4-dihydronaphthalen-1(2h)-one (CAS 345-08-4)
- 3-Ethynyl-5-(trifluoromethyl)pyridin-2-amine (CAS 1048914-02-8)
- Chlorofluoroacetyl Chloride (CAS 359-32-0)
- Europium(III) phosphate hydrate (CAS 13537-10-5)
- Methyl 4-hydroxy-1-methylpiperidine-4-carboxylate hydrochloride (CAS 1992939-83-9)
- 2-Chloro-N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide (CAS 7659-20-3)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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