2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)-ethanone CAS 683274-74-0
| CAS No. | 683274-74-0 |
| Molecular Formula | C10H10BrClO2 |
| Molecular Weight | 277.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)-ethanone.
2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)-ethanone (CAS 683274-74-0) is a high-purity analytical reference standard with the molecular formula C10H10BrClO2 and a molecular weight of 277.54 g/mol.
The molecular framework of 2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)-ethanone (C10H10BrClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Bromo-1-(5-chloro-2-methoxy-4-methylphenyl)-ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10BrClO2 |
| Molecular Weight | 277.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl/Br-containing |
Related Bromo Standards
- 2-Bromo-1-(3-chloro-4-methoxyphenyl)propan-1-one (CAS 102976-53-4)
- Ethyl 4-bromo-5-chloro-2-methylbenzoate (CAS 1033436-15-5)
- 5-Bromo-2-isopropoxybenzoyl chloride (CAS 116477-99-7)
- Ethyl 2-(3-bromo-4-chlorophenyl)acetate (CAS 1208076-13-4)
- 1-(5-Bromo-3-chloro-2-hydroxyphenyl)butan-1-one (CAS 1249651-77-1)
- 4-Bromo-2-chlorobenzeneacetic Acid Ethyl Ester (CAS 1261606-45-4)
- Ethyl 4-bromo-3-chlorophenylacetate (CAS 1261791-56-3)
- Methyl 2-(4-bromo-2-chloro-5-methylphenyl)acetate (CAS 1428761-26-5)
Recommended Standards
- 2-(Bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane (CAS 3418-24-4)
- 3-Bromo-2-chloro-5-isopropylbenzoic acid (CAS 2379321-70-5)
- 2-(6-Bromo-2-chloro-3-methylphenyl)-1,3-Dioxolane (CAS 2221812-36-6)
- 4-(2-Bromo-5-chlorophenyl)butanoic acid (CAS 947614-96-2)
- 2,6-Di-tert-butylanthracene-9,10-dione (CAS 18800-99-2)
- 5-Methylfuro[2,3-d]pyrimidin-2-amine (CAS 1498359-65-1)
- 8-Tert-butoxycarbonyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylicacid (CAS 2309122-41-4)
- Avibactam Impurity 129 (CAS CATO-C4X-1348129)
- 1,2,5-Trimethyl-2,3-dihydro-1H-pyrazol-3-yl benzoate (CAS 62031-03-2)
- methyl 3-(4-{[(tert-butoxy)carbonyl]amino}piperidin-1-yl)propanoate (CAS 294180-26-0)
- 2-[(cyclopropylcarbamoyl)amino]acetic acid (CAS 953906-56-4)
- 4,4-Dimethyl-2-(1,10-phenanthrolin-2-yl)-4,5-dihydrooxazole (CAS 1101906-42-6)
- 3-Chloromethyl-1-methylpiperidine hydrochloride (CAS 66496-82-0)
- Semaglutide Main Chain P29 (CAS 1169630-82-3)
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