5-(4-Methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine CAS 685107-94-2
| CAS No. | 685107-94-2 |
| Molecular Formula | C20H14F3N3O3S |
| Molecular Weight | 433.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine.
CATO supplies 5-(4-Methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 685107-94-2), a certified reference material (molecular formula C20H14F3N3O3S, MW 433.40 g/mol) for analytical method development and quality control.
The molecular framework of 5-(4-Methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (C20H14F3N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H14F3N3O3S |
| Molecular Weight | 433.40 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methoxyphenyl Standards
- 5-(2-Methoxyphenyl)-3-(phenylsulfonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 685107-95-3)
- 1-((5-(3-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-5-(3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-2(1H)-one (CAS 1396857-79-6)
- 3-(4-Methoxyphenyl)-5-phenyl-1H-pyrazole (CAS 32664-28-1)
- Methyl 2-({[1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-yl]methyl}sulfanyl)benzoate (CAS 866049-18-5)
- 4-Ethyl-3-{[(4-methoxyphenyl)methyl]sulfanyl}-5-{4H,5H-naphtho[1,2-b]thiophen-2-yl}-4H-1,2,4-triazole (CAS 477887-91-5)
- 7-(4-Methoxyphenyl)-2-(4-(m-tolyl)piperazin-1-yl)thieno[3,2-d]pyrimidin-4-ol (CAS 1226427-52-6)
- 4-(2-Methoxyphenyl)-5-(4-(morpholinosulfonyl)phenyl)-4H-1,2,4-triazole-3-thiol (CAS 917749-91-8)
- 1,2-Bis(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole (CAS 21124-69-6)
Recommended Standards
- Methyl 2-(4,5-dimethoxy-2-(N-(4-(trifluoromethyl)phenyl)sulfamoyl)phenyl)acetate (CAS 886498-97-1)
- 3-Nitro-4-(phenylthio)benzyl 3-(trifluoromethyl)benzoate (CAS 320424-14-4)
- N-[3,5-Bis(trifluoromethyl)phenyl]-4-phenylpiperazine-1-carbothioamide (CAS 104017-61-0)
- 3-(Benzenesulfonyl)-5-(3-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 685108-20-7)
- 3,3-Dimethyl-2-methylene-1-phenylindoline (CAS 5227-71-4)
- (1R,2S)-ethyl 2-(3-amino-4-(diisobutylamino)phenyl)cyclopropanecarboxylate (CAS 1629126-20-0)
- 1-(1-Bromopropyl)-2,4,6-Trifluorobenzene (CAS 1247452-70-5)
- 7-Bromo-5,8-difluoro-3,4-dihydronaphthalen-1(2H)-one (CAS 1341073-10-6)
- (2-Iodophenyl)methanamine hydrochloride (CAS 42365-45-7)
- 4-Bromo-5-methylpyridine-2-carboxaldehyde (CAS 1196157-14-8)
- 1-(4-Methoxyphenyl)-2(1H)-pyridinone 1-(4-Methoxyphenyl)pyridin-2(1H)-one 725256-40-6 (CAS 725256-40-6)
- 5-Bromo-7-isopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 1337533-24-0)
- rel-(4R,4′R)-2,2′-(1,3-Phenylene)bis[4,5-dihydro-4-(1-methylethyl)oxazole] (CAS 188255-26-7)
- Liraglutide Impurity 16 TFA Salt (CAS CATO-C4X-199216)
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