3-Chloro-2,6-difluoroisonicotinic acid CAS 685517-75-3
| CAS No. | 685517-75-3 |
| Molecular Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 3-Chloro-2,6-difluoroisonicotinic acid (CAS 685517-75-3), a certified reference material (molecular formula C6H2ClF2NO2, MW 193.54 g/mol) for analytical method development and quality control.
3-Chloro-2,6-difluoroisonicotinic acid (C6H2ClF2NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-Chloro-2,4-difluoro-3-nitrobenzene (CAS 1151767-58-6)
- 5-Chloro-1,3-difluoro-2-nitrobenzene (CAS 136272-31-6)
- 1-Chloro-2,4-difluoro-5-nitrobenzene, 97% (CAS 1481-68-1)
- 1-Chloro-2,3-difluoro-4-nitrobenzene (CAS 169468-80-8)
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- 1-Chloro-2,5-difluoro-3-nitrobenzene (CAS 1805029-24-6)
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Recommended Standards
- 2-Chloro-4,5-difluoronitrobenzene (CAS 771-76-6)
- 3-Chloro-5,6-difluoropicolinic acid (CAS 406676-40-2)
- 2-Chloro-3,5-difluoronitrobenzene (CAS 36556-59-9)
- 4-Chloro-2,5-difluoropyridine-3-carboxylic acid (CAS 851386-42-0)
- tert-Butyl(dibromomethyl)dimethylsilane (CAS 148259-35-2)
- Ethylene-β-ionol (CAS 59057-30-6)
- (S)-2-Acetamido-3-(4-hydroxy-3-iodophenyl)propanoic acid (CAS 1023-47-8)
- (2S,3R)-3-Amino-2-methyl-3-phenylpropanoic acid hydrochloride (CAS 16933-84-9)
- (4-(1-Hydroxyethyl)phenyl)(phenyl)methanone (CAS 85696-44-2)
- Ethyl-1-d1 Alcohol (CAS 1624-36-8)
- 2-(2-Bromo-6-fluorophenyl)acetic acid (CAS 1214322-99-2)
- N-(4-Chlorobenzyl)-4-(2-cyclohexylethoxy)aniline (CAS 1040693-12-6)
- Delafloxacin Impurity 18 (CAS CATO-C4X-263718)
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