Pramipexole Impurity 60 CAS 687639-03-8
| CAS No. | 687639-03-8 |
| Molecular Formula | C8H12BrNO2 |
| Molecular Weight | 234.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pramipexole Impurity 60 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Pramipexole Impurity 60 (CAS 687639-03-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12BrNO2 and a molecular weight of 234.09 g/mol.
Pramipexole Impurity 60 (C8H12BrNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pramipexole Impurity 60 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12BrNO2 |
| Molecular Weight | 234.09 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Pramipexole Standards
- Pramipexole Impurity 69 (CAS CATO-C4X-110769)
- Pramipexole Impurity 38 (CAS 1217680-69-7)
- Pramipexole Impurity 33 (CAS 17557-67-4)
- Pramipexole Impurity 96 (CAS CATO-C4X-110796)
- Pramipexole Impurity 11 （and enantiomer） (CAS 1246818-51-8)
- Pramipexole USP Related Compound G (CAS 1001648-71-0)
- Pramipexole Impurity 22 (CAS CATO-C4X-110722)
- Pramipexole Impurity 93 (CAS 1965329-42-3)
Recommended Standards
- (E)-1-bromo-4-(2-nitrovinyl)benzene 1-(4-Bromophenyl)-2-nitroethene 5153-71-9 (CAS 5153-71-9)
- 1-Allyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1000801-78-4)
- 7-bromo-3-methyl-1,3-benzoxazol-2-one (CAS 889884-73-5)
- 6-(Methylamino)pyridine-3-boronic Acid Pinacol Ester (CAS 1005009-98-2)
- Tenofovir alafenamide Impurity 96 (CAS CATO-C4X-179796)
- Glimepiride Impurity 18 (CAS 41176-69-6)
- Salcaprozate Impurity 4 (CAS CATO-C4X-25074)
- (6S)-1,4-oxazepan-6-ol (CAS 1373232-31-5)
- Methyl 2-(6-chloro-2-oxoindolin-5-yl)acetate (CAS 510703-84-1)
- 5-(4-(Methoxymethyl)phenyl)-5-oxopentanoic acid (CAS 1443311-09-8)
- 2-(Difluoromethyl)-5-hydroxypyridine-4-carboxaldehyde (CAS 1805275-56-2)
- 5-(3-(Dimethylamino)pyrrolidin-1-yl)thiophene-2-carboxylic acid (CAS 1344288-82-9)
- 2-azido-1,1-diethoxyethane (CAS 113738-28-6)
- Insulin Glargine Metabolite M2 (CAS CATO-CPTD788867)
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