2-(4-Chlorobenzyl)piperidine hydrochloride CAS 6936-90-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Chlorobenzyl)piperidine hydrochloride.

2-(4-Chlorobenzyl)piperidine hydrochloride (CAS 6936-90-9), molecular formula C12H16ClNHCl and molecular weight 246.18 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(4-Chlorobenzyl)piperidine hydrochloride (C12H16ClNHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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