4-Chloro-6-methyl-N-phenylpyrimidin-2-amine CAS 6967-54-0
| CAS No. | 6967-54-0 |
| Molecular Formula | C11H10ClN3 |
| Molecular Weight | 219.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-6-methyl-N-phenylpyrimidin-2-amine.
4-Chloro-6-methyl-N-phenylpyrimidin-2-amine (CAS 6967-54-0) is a high-purity analytical reference standard with the molecular formula C11H10ClN3 and a molecular weight of 219.67 g/mol.
The molecular framework of 4-Chloro-6-methyl-N-phenylpyrimidin-2-amine (C11H10ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-6-methyl-N-phenylpyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10ClN3 |
| Molecular Weight | 219.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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Recommended Standards
- 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (CAS 607738-99-8)
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