7-Chloro-2-methylquinazolin-4(1H)-one CAS 7012-88-6
| CAS No. | 7012-88-6 |
| Molecular Formula | C9H7ClN2O |
| Molecular Weight | 194.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Chloro-2-methylquinazolin-4(1H)-one.
7-Chloro-2-methylquinazolin-4(1H)-one (CAS 7012-88-6) is a high-purity analytical reference standard with the molecular formula C9H7ClN2O and a molecular weight of 194.62 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 7-Chloro-2-methylquinazolin-4(1H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 194.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClN2O |
| Molecular Weight | 194.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-6-methyl-7H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (CAS 1000340-13-5)
- 4-Chloro-7-methyl-1H-indazole-3-carbaldehyde (CAS 1000340-67-9)
- 6-(4-Chloro-1H-pyrazol-1-yl)pyridin-3-amine (CAS 1006961-40-5)
- 4-Chloro-1-methyl-1,8-naphthyridin-2(1H)-one (CAS 1009360-86-4)
- 4-Chloro-6-(4-methylpyrazol-1-yl)pyrimidine (CAS 1015845-71-2)
- 6-Chloro-n-(prop-2-yn-1-yl)pyridine-3-carboxamide (CAS 1017047-71-0)
- 2-Chloro-5-(4H-1,2,4-triazol-4-yl)aniline (CAS 1017791-27-3)
- 2-Chloro-1-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethanone (CAS 102014-84-6)
Recommended Standards
- 7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 64500-18-1)
- 7-Chloro-3-methyl-3,4-dihydroquinazolin-4-one (CAS 201298-39-7)
- 7-Chloro-1-methyl-1,8-naphthyridin-2(1H)-one (CAS 69099-05-4)
- 7-Chloro-6-methylquinazolin-4-ol (CAS 860193-26-6)
- (5-Amino-1-(4-chlorophenyl)-1H-pyrazol-4-yl)(4-methoxyphenyl)methanone (CAS 618091-25-1)
- (S)-1-(3,4-dichlorophenyl)-2,2-dimethylpropan-1-amine (CAS 1388128-61-7)
- n-(Sec-butyl)-2-chloro-4-nitroaniline (CAS 1042521-01-6)
- Pavinetant (CAS 941690-55-7)
- 3-((4-(Tert-butyl)cyclohexyl)amino)propan-1-ol (CAS 1024275-21-5)
- 5,6-Diethyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 54089-09-7)
- (E)-4-(((4-Fluorophenyl)imino)methyl)phenol (CAS 942485-62-3)
- 2-(((1H-Pyrrol-2-yl)methylene)amino)ethanesulfonic acid (CAS 71691-06-0)
- 2,3-Dibromo-5-(difluoromethyl)pyridin-4-amine (CAS 1806785-17-0)
- Fibrinogen-Binding Inhibitor Peptide (CAS 89105-94-2)
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