5-Fluoro-2-methoxybenzoyl chloride CAS 704-03-0
| CAS No. | 704-03-0 |
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Fluoro-2-methoxybenzoyl chloride.
CATO supplies 5-Fluoro-2-methoxybenzoyl chloride (CAS 704-03-0), a certified reference material (molecular formula C8H6ClFO2, MW 188.58 g/mol) for analytical method development and quality control.
The molecular framework of 5-Fluoro-2-methoxybenzoyl chloride (C8H6ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Fluoro Standards
- 4-Fluoro-3-methylphenyl Chloroformate (CAS 1001095-14-2)
- 3-Fluoro-2-methoxybenzoyl chloride (CAS 106428-06-2)
- 3-Fluoro-5-methoxybenzoyl chloride (CAS 1092789-19-9)
- 4-Fluoro-3-(chloromethyl)benzoic acid (CAS 1378830-30-8)
- 4-Fluoro-2-methylphenyl Chloroformate (CAS 1552201-86-1)
- 2-Fluoro-3-methoxybenzoyl chloride (CAS 850563-45-0)
- 2-Fluoro-4-methoxybenzoyl Chloride (CAS 321-24-4)
- 2-Fluoro-5-methoxybenzoyl chloride (CAS 659737-56-1)
Recommended Standards
- 5-Chloro-4-fluoro-2-methoxybenzaldehyde (CAS 889858-36-0)
- 6-(Chloromethyl)-4-fluorobenzo[d][1,3]dioxole (CAS 945244-10-0)
- 5-chloro-2-trifluoromethyl-pyrimidine (CAS 845618-08-8)
- 6-Chloro-2-fluoro-3-methylbenzoic Acid (CAS 32890-90-7)
- 2-(2,6-Dibromophenoxy)ethane-1-sulfonyl chloride (CAS 1342261-88-4)
- 3-(4-(Methoxycarbonyl)thiazol-2-yl)bicyclo[1.1.1]Pentane-1-carboxylic acid (CAS 1980063-87-3)
- 1,4-Diamino-2,3-dihydroanthracene-9,10-dione (CAS 81-63-0)
- 61568-36-3 CTK2D7242 Thiophene, 2-ethyltetrahydro-3-methyl-, trans- (CAS 61568-36-3)
- 1-Ethyl-3-isobutyl-1h-pyrazole-5-carboxylic acid (CAS 1015845-75-6)
- 5-(chloromethyl)-1-(4-methoxyphenyl)-1H-1,2,3,4-tetrazole (CAS 941867-78-3)
- 2-(2-Methylallyl)cycloheptan-1-ol (CAS 1249369-83-2)
- 5-(1h-Pyrazol-1-yl)pentanenitrile (CAS 1248790-67-1)
- tert-Butyl ((6-ethoxypyridin-3-yl)methyl)carbamate (CAS 1355229-69-4)
- Insulin Degludec Impurity 19 (CAS CATO-C4X-215719)
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