2,2-Difluoro-1-(p-tolyl)ethan-1-one CAS 704-36-9
| CAS No. | 704-36-9 |
| Molecular Formula | C9H8F2O |
| Molecular Weight | 170.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2,2-Difluoro-1-(p-tolyl)ethan-1-one (CAS 704-36-9), a certified reference material (molecular formula C9H8F2O, MW 170.16 g/mol) for analytical method development and quality control.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,2-Difluoro-1-(p-tolyl)ethan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 170.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F2O |
| Molecular Weight | 170.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 4,7-difluoro-2,3-dihydro-1H-inden-1-ol (CAS 130408-17-2)
- 1-(3,6-Difluoro-2-methylphenyl)ethan-1-one (CAS 1379339-99-7)
- 1-(3,5-Difluoro-2-methylphenyl)ethan-1-one (CAS 1557818-59-3)
- 5,7-Difluoro-2,3-dihydro-1H-inden-1-ol (CAS 173996-15-1)
- 4,6-Difluoro-2,3-dihydro-1H-inden-1-ol (CAS 173998-55-5)
- 1-(2,4-Difluoro-5-methylphenyl)ethan-1-one (CAS 177211-27-7)
- 1-(2,5-Difluoro-4-methylphenyl)ethanone (CAS 178696-17-8)
- 2,5-Difluoro-3-methylacetophenone (CAS 1803833-34-2)
Recommended Standards
- 2,2-Difluoro-1-(o-tolyl)ethan-1-one (CAS 703-42-4)
- 2,2-Difluoro-1-phenyl-1-propanone (CAS 703-17-3)
- 2,2-Difluoro-1-(m-tolyl)ethan-1-one (CAS 50562-05-5)
- 2,2-Dimethyl-4-oxo-3,4-dihydro-2H-pyran-6-carboxylic acid (CAS 80866-93-9)
- (2R,3R,4S,5R)-2-(6-Amino-8-((E)-styryl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 833445-96-8)
- (R)-2-Methyl-1-(pyrrolidin-1-yl)butan-1-one (CAS 667420-91-9)
- 3-(Propan-2-yl)-1,2,4-oxadiazol-5-amine (CAS 3874-89-3)
- 1-(2-{[(2-Methylbenzoyl)oxy]imino}cyclohexyl)-2,4-dinitrobenzene (CAS 383147-88-4)
- 2-(3-Hydroxyphenyl)-1-(4-morpholinyl)ethanethione 3-Hydroxyphenylthioacetmorpholide 4-[2-(3-Hydroxyphenyl)-1-thioxoethyl]morpholine 4-[[m-Hydroxyphenyl]thioacetyl]morpholine 500284-27-5 NSC 24140 |A-(Morpholinothiocarbonyl)-M-cresol (CAS 500284-27-5)
- Cyclohexyl(pyridin-2-yl)methanone (CAS 6602-64-8)
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