Bisoprolol Impurity 63 CAS 704200-67-9
| CAS No. | 704200-67-9 |
| Molecular Formula | C15H23ClO4 |
| Molecular Weight | 302.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Bisoprolol Impurity 63 (CAS 704200-67-9) is a certified pharmaceutical impurity reference standard with the molecular formula C15H23ClO4 and a molecular weight of 302.79 g/mol.
Structurally, Bisoprolol Impurity 63 (C15H23ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 302.79 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bisoprolol Impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H23ClO4 |
| Molecular Weight | 302.79 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Bisoprolol Standards
- Bisoprolol EP Impurity E (CAS 1217245-60-7)
- Bisoprolol EP Impurity Q (CAS 1346604-00-9)
- Bisoprolol Hydroxyethyl Ester Impurity (CAS 1346601-19-1)
- Bisoprolol Impurity N5 (CAS 109791-19-7)
- Bisoprolol Impurity 107 (CAS CATO-C4X-1247107)
- Bisoprolol Impurity 108 (CAS 2615193-96-7)
- Bisoprolol Impurity 35 (CAS 1346602-59-2)
- Bisoprolol EP Impurity N (CAS 1346601-75-9)
Recommended Standards
- 6125-34-4 2-Chloro-N-[4-(1-naphthyl)-1,3-thiazol-2-yl]acetamide MFCD03362968 (CAS 6125-34-4)
- 4-(4-Benzylpiperazin-1-yl)-6-chloro-2-methylpyrimidine (CAS 1017782-74-9)
- 1578AE 2-Chloro-N-[4-(pyrrolidin-1-ylsulfonyl)phenyl]-acetamide 35974-26-6 C12H15ClN2O3S (CAS 35974-26-6)
- (2Z)-2-(4-Chlorobenzenesulfonyl)-3-(methylamino)-3-(methylsulfanyl)prop-2-enenitrile (CAS 1025276-52-1)
- Bumetanide Impurity 20 (CAS CATO-C4X-198620)
- Ceftazidime Impurity 58 (CAS CATO-C4X-121258)
- Dotinurad Impurity 151 (CAS CATO-C4X-2494151)
- 3-(3-aminophenyl)propyl acetate (CAS 1379353-36-2)
- Lacosamide Impurity 56 (CAS CATO-C4X-183056)
- tert-Butyl 4-(4-cyanophenyl)-4-hydroxypiperidine-1-carboxylate (CAS 871112-38-8)
- 5-Hydroxy-5-methylhydantoin (CAS 10045-58-6)
- Methyl 5-bromo-2-((tert-butoxycarbonyl)amino)benzoate (CAS 851314-03-9)
- N-(1-(Furan-2-yl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (CAS 1219913-41-3)
- Renin Inhibitor Peptide (CAS 50410-01-0)
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