4,6-Dichloro-2-(trifluoromethyl)pyrimidine CAS 705-24-8
| CAS No. | 705-24-8 |
| Molecular Formula | C5HCl2F3N2 |
| Molecular Weight | 216.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4,6-Dichloro-2-(trifluoromethyl)pyrimidine (CAS 705-24-8), molecular formula C5HCl2F3N2 and molecular weight 216.98 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,6-Dichloro-2-(trifluoromethyl)pyrimidine (C5HCl2F3N2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5HCl2F3N2 |
| Molecular Weight | 216.98 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- 2,3-Dichloro-5-(trifluoromethyl)pyrazine (CAS 1238230-17-5)
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- 4,5-Dichloro-6-(trifluoromethyl)pyrimidine (CAS 141602-36-0)
- 2,4-Dichloro-6-trifluoromethylpyrimidine (CAS 16097-64-6)
- 2,5-Dichloro-4-(trifluoromethyl)pyrimidine (CAS 785777-98-2)
- 4,6-Dichloro-5-(trifluoromethyl)pyrimidine (CAS 392298-44-1)
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- (E)-Methyl 4-(4-cyanophenyl)-2-oxobut-3-enoate (CAS 1257520-11-8)
- Thietane-2-carboxylic acid 1,1-dioxide (CAS 1785450-70-5)
- Methyl 7-cyclopropyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5-carboxylate (CAS 1795433-31-6)
- 2-(5-(Pyridin-2-yl)-1H-1,2,4-triazol-3-yl)pyrazine (CAS 36762-84-2)
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