n-(3-Chloro-4-nitrophenyl)acetamide CAS 712-33-4
| CAS No. | 712-33-4 |
| Molecular Formula | C8H7ClN2O3 |
| Molecular Weight | 214.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
n-(3-Chloro-4-nitrophenyl)acetamide (CAS 712-33-4), molecular formula C8H7ClN2O3 and molecular weight 214.61 g/mol, is a CATO reference standard with documented purity and traceability.
n-(3-Chloro-4-nitrophenyl)acetamide (C8H7ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClN2O3 |
| Molecular Weight | 214.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related n Standards
- 2-Chloro-N-(2-nitrophenyl)acetamide (CAS 10147-70-3)
- 2-Chloro-n-(3-nitrophenyl)acetamide (CAS 10147-71-4)
- 6-Chloro-7-nitro-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 1198475-26-1)
- 2-Chloro-4-cyclopropoxy-5-nitropyridine (CAS 1243319-63-2)
- 2-Chloro-5-cyclopropoxy-3-nitropyridine (CAS 1243350-30-2)
- 3-Chloro-5-cyclopropoxy-2-nitropyridine (CAS 1243410-76-5)
- 2-Chloro-3-cyclopropoxy-6-nitropyridine (CAS 1243449-70-8)
- 5-Chloro-3-cyclopropoxy-2-nitropyridine (CAS 1243450-11-4)
Recommended Standards
- N-(3-chloro-2-nitrophenyl)acetamide (CAS 99233-27-9)
- N-(3-Chlorophenyl)-2-nitroacetamide (CAS 99233-26-8)
- N-(2-chloro-5-nitrophenyl)acetamide (CAS 4031-81-6)
- N-(4-chloro-2-nitrophenyl)acetamide (CAS 881-51-6)
- 4-(2-(trans-4-Ethylcyclohexyl)ethyl)cyclohexanone (CAS 1432597-99-3)
- 1-(4-Chlorophenyl)-3-(4-methylbenzenesulfonyl)urea (CAS 3955-50-8)
- 2-(4-((3,4-Dichlorobenzyl)oxy)phenyl)-1,3,4-oxadiazole (CAS 338393-67-2)
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- 1-(Azetidin-3-yl)-4-nitro-1H-pyrazole (CAS 1341381-32-5)
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- 6-(4-((2,5-Dichloropyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile (CAS 1903768-77-3)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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