3-(trifluoromethyl)-2,5-dihydrothiophene 1,1-Dioxide CAS 71654-38-1
| CAS No. | 71654-38-1 |
| Molecular Formula | C5H5F3O2S |
| Molecular Weight | 186.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(trifluoromethyl)-2,5-dihydrothiophene 1,1-Dioxide.
3-(trifluoromethyl)-2,5-dihydrothiophene 1,1-Dioxide (CAS 71654-38-1) is a high-purity analytical reference standard with the molecular formula C5H5F3O2S and a molecular weight of 186.15 g/mol.
The molecular framework of 3-(trifluoromethyl)-2,5-dihydrothiophene 1,1-Dioxide (C5H5F3O2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(trifluoromethyl)-2,5-dihydrothiophene 1,1-Dioxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F3O2S |
| Molecular Weight | 186.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related trifluoromethyl Standards
- 4-(Trifluoromethyl)-2,3-dihydrothiophene 1,1-dioxide (CAS 71654-37-0)
- 3-[(4-Trifluoromethyl)phenyl]-1-propene (CAS 1813-97-4)
- (2-(Trifluoromethyl)cyclopropyl)benzene (CAS 1822956-84-2)
- 3-[(2-Trifluoromethyl)phenyl]-1-propene (CAS 62826-30-6)
- 4-(Trifluoromethyl)-1H-indazole (CAS 1000339-98-9)
- 2-(3-(Trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1000512-60-6)
- 2-(Trifluoromethyl)pyridine-3-acetonitrile (CAS 1000529-97-4)
- 2-(4-(Trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1000536-10-6)
Recommended Standards
- (2,4-Diaminopyrimidin-5-yl)dimethylphosphine oxide (CAS 2460756-88-9)
- 3-Pyridinol, 6-amino-5-(dimethylphosphinyl)- (CAS 2886000-57-1)
- 5-fluoro-2-(trifluoromethyl)pyridin-4-amine (CAS 1260663-77-1)
- Osimertinib Impurity 44 (CAS CATO-C4X-204544)
- Glycocholic acid 3-O-β-glucuronide, 98% (CAS 99794-78-2)
- 2,4-Dinitrophenylhydrazine-d3 (CAS 259824-49-2)
- 4-Chloro-6-(difluoromethyl)-5-(trifluoromethyl)pyridin-2-ol (CAS 1806931-30-5)
- 1-(1-Vinyl-1H-indol-3-yl)ethanone (CAS 491613-17-3)
- 1-Benzyl-3,3-dimethylpiperidin-4-ol (CAS 324769-02-0)
- n-(2-Fluorobenzyl)piperidine-4-carboxamide (CAS 923138-49-2)
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- 6,7-Methylenedioxy-4-methyl-3-maleimidocoumarin [for HPLC Labeling] (CAS 97744-90-6)
- Ethyl cis-3-amino-1-methylcyclobutanecarboxylate (CAS 1408075-83-1)
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