Ethyl (2Z)-3-(dimethylamino)-2-isocyanoacrylate CAS 72130-97-3
| CAS No. | 72130-97-3 |
| Molecular Formula | C8H12N2O2 |
| Molecular Weight | 168.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl (2Z)-3-(dimethylamino)-2-isocyanoacrylate (C8H12N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Ethyl (2Z)-3-(dimethylamino)-2-isocyanoacrylate (CAS 72130-97-3), a certified reference material (molecular formula C8H12N2O2, MW 168.19 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Ethyl (2Z)-3-(dimethylamino)-2-isocyanoacrylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O2 |
| Molecular Weight | 168.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 2 |
Recommended Standards
- ethyl (2S,5S)-5-cyanopyrrolidine-2-carboxylate (CAS 435274-88-7)
- ethyl (2Z)-3-(dimethylamino)-2-isocyanoacrylate (CAS 927885-99-2)
- Ethyl (2S,5R)-5-cyanopyrrolidine-2-carboxylate (CAS 435274-89-8)
- Ethyl (E)-2-cyano-3-(dimethylamino)acrylate (CAS 57338-21-3)
- N1-Butyl-N2-cyclohexylethane-1,2-diamine (CAS 886502-85-8)
- 4-Amino-3-(4-methoxy-phenyl)-butyric acidhydrochloride (CAS 432049-65-5)
- 4-Bromothiophene-3-carbonitrile (CAS 18895-10-8)
- Methyl 3-(1H-1,2,4-triazol-3-yl)benzoate (CAS 118863-65-3)
- 3-(6-Hydroxy-2-isopropenyl-2,3-dihydro-benzofuran-5-yl)-acrylic acid (CAS 354147-13-0)
- 4-Amino-6,7-dimethoxyquinazolin-2(1h)-one (CAS 664347-52-8)
- Ethyl 3-(6-methoxynaphthalen-2-yl)-3-oxopropanoate (CAS 62550-56-5)
- 4-Bromo-N-(3-cyanothiophen-2-yl)benzamide (CAS 865545-75-1)
- 3-Cyclobutyl-2-((thietan-3-ylamino)methyl)propan-1-ol (CAS 1880305-44-1)
- Peptide 442 (CAS CATO-CPTD788442)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com