1,4-Bis(phenylsulfonyl)piperazine CAS 7250-99-9
| CAS No. | 7250-99-9 |
| Molecular Formula | C16H18N2O4S2 |
| Molecular Weight | 366.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1,4-Bis(phenylsulfonyl)piperazine is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1,4-Bis(phenylsulfonyl)piperazine (CAS 7250-99-9), molecular formula C16H18N2O4S2 and molecular weight 366.46 g/mol, is a CATO reference standard with documented purity and traceability.
1,4-Bis(phenylsulfonyl)piperazine (C16H18N2O4S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18N2O4S2 |
| Molecular Weight | 366.46 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Bis Standards
- N-(1-(Phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)methanesulfonamide (CAS 951485-45-3)
- 3,4-Bis(phenylsulfonyl)-1,2,5-oxadiazole 2-Oxide (CAS 66074-00-8)
- 4-{[Phenyl(phenylsulfonyl)amino]methyl}benzoic acid (CAS 331750-21-1)
- 8-(Phenylsulfonyl)-6-(pyridin-2-ylamino)-2,3-dihydroindolizin-5(1H)-one (CAS 612065-29-9)
- 2-Phenyl-5-(1-(phenylsulfonyl)-1H-pyrazol-3-yl)thiazole (CAS 318248-80-5)
- Ethyl 8-(phenylsulfonyl)-1,8-dihydropyrrolo[2,3-b]indole-2-carboxylate (CAS 182257-99-4)
- Ethyl 4-(phenylsulfonyl)-2,4-dihydropyrrolo[3,4-b]indole-3-carboxylate (CAS 182258-03-3)
- (1-(Phenylsulfonyl)piperidine-4-carbonyl)valine (CAS 1009342-65-7)
Recommended Standards
- 1,2-Bis(4'-methyl-[2,2'-bipyridin]-4-yl)ethane (CAS 96897-04-0)
- 1-[1-[2-Oxo-2-(1,2,5-trimethyl-3-pyrrolyl)ethyl]-4-piperidinyl]-1H-benzo[d]imidazol-2(3H)-one (CAS 924108-75-8)
- 1,1'-(Dodecane-1,12-diyl)bis(imidazolidine-2,4-dione) (CAS 94134-11-9)
- 2-((1-(2-Hydroxyethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide (CAS 899743-04-5)
- 4-Methoxy-3-methyl-2H-chromen-2-one (CAS 26952-87-4)
- 3-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1605330-55-9)
- Atovaquone Impurity 1 (CAS 49708-81-8)
- Belumosudil Impurity 60 (CAS CATO-C4X-298860)
- 2-Chloro-N-(3-cyano-4-((4-methoxyphenyl)sulfonyl)phenyl)benzamide (CAS 477866-67-4)
- (4-Chlorophenylthio)acetonitrile (CAS 18527-19-0)
- TG4-155 (CAS 1164462-05-8)
- N/A (CAS CATO-CQCM100830)
- 3-((4-Acetylpiperazin-1-yl)sulfonyl)thiophene-2-carboxylic acid (CAS 1097090-64-6)
- D-Ile17-Tirzepatide (CAS CATO-CPTD788917)
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