1-(1-(3-(Aminomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea CAS 725686-05-5
| CAS No. | 725686-05-5 |
| Molecular Formula | C21H24ClN5O |
| Molecular Weight | 397.90 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(1-(3-(Aminomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea (CAS 725686-05-5) is a high-purity analytical reference standard with the molecular formula C21H24ClN5O and a molecular weight of 397.90 g/mol.
The molecular framework of 1-(1-(3-(Aminomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea (C21H24ClN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 1-(1-(3-(Aminomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H24ClN5O |
| Molecular Weight | 397.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
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Recommended Standards
- N-(4-Chloro-3-methylphenyl)-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775472-09-7)
- 1,4-Diiodo-2-(trifluoromethyl)benzene (CAS 518343-63-0)
- N-[(3-Chlorophenyl)methyl]-5-methyl-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775408-93-9)
- (S)-Azelastine N-Oxide (Mixture of Diastereomers) (CAS 1346617-06-8)
- 1-(2-Amino-5-(piperidin-1-yl)phenyl)ethan-1-one (CAS 60283-14-9)
- (5-(3-Chlorophenyl)-1H-1,2,4-triazol-3-yl)methanol (CAS 1501934-45-7)
- (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (CAS 2244684-40-8)
- Sodium (R)-2,3-bis(((E)-docos-13-enoyl)oxy)propyl (2,3-dihydroxypropyl) phosphate (CAS 1241726-12-4)
- rel-tert-Butyl (3aR,6aS)-4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (CAS 130658-14-9)
- 2-Chloro-N-{2-[(2-cyano-2-methylethyl)sulfanyl]phenyl}acetamide (CAS 1269152-15-9)
- 1-Isobutyl-3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2096332-54-4)
- 2-(Difluoromethyl)-3-iodo-4-nitropyridine-6-acetic acid (CAS 1807096-27-0)
- 3-((4-Cyanophenyl)amino)-3-oxopropanoic acid (CAS 1100767-21-2)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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