Fosinopril Impurity 1 CAS 72651-25-3

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.72651-25-3
Molecular FormulaC3H7O4P
Molecular Weight138.06 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Fosinopril Impurity 1 CAS 72651-25-3 chemical structure

Description

As a process- or degradation-related impurity, Fosinopril Impurity 1 (CAS 72651-25-3, C3H7O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Fosinopril Impurity 1 (C3H7O4P) contains a phosphate ester group, a carboxylic acid group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC3H7O4P
Molecular Weight138.06 g/mol
Purity97%+
StorageStore at 2-8°C, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityHygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)0.5
CAS Registry Year (est.)1977

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