1-(4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl)quinazolin-4(1H)-one CAS 727376-92-3
| CAS No. | 727376-92-3 |
| Molecular Formula | C21H20F4N2O3 |
| Molecular Weight | 424.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl)quinazolin-4(1H)-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl)quinazolin-4(1H)-one (CAS 727376-92-3), molecular formula C21H20F4N2O3 and molecular weight 424.39 g/mol, is a CATO reference standard with documented purity and traceability.
1-(4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl)quinazolin-4(1H)-one (C21H20F4N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 1-(4-(5-Fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl)quinazolin-4(1H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H20F4N2O3 |
| Molecular Weight | 424.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- 2'-Fluoro-[1,1':4',1"-terphenyl]-3,3",5,5"-tetracarboxylic acid (CAS 2392973-69-0)
- 3-[1-(3-Fluoro-4-methoxybenzoyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775335-58-4)
- 3'-Fluoro-2,4,4'-tribromodiphenyl ether (CAS 876310-22-4)
- 4'-Fluoro-2,3',4-tribromodiphenyl ether (CAS 863314-85-6)
- 4'-Fluoro-2,3',6-tribromodiphenyl ether (CAS 863314-86-7)
- Methyl7-(2-fluoro-4-iodo-anilino)-8-methyl-imidazo[1,2-a]pyridine-6-carboxylate (CAS 2306264-81-1)
- [6-(5-Fluoro-pyridin-2-yloxymethyl)-2-methyl-azepan-1-yl]-(5-methyl-2-oxazol-2-yl-phenyl)-methanone (CAS 1224374-22-4)
- Ethyl 2-((5-fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-6-methylpyrimidin-4-yl)sulfonyl)acetate (CAS 1823188-22-2)
Recommended Standards
- tert-Butyl(3-iodopropoxy)diphenylsilane (CAS 114671-83-9)
- Ethyl 3-((6-(benzo[d][1,3]dioxol-5-yl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)propanoate (CAS 625376-94-5)
- NVP-BAW2881, >98% (HPLC) (CAS 861875-60-7)
- N-(3-(benzyloxy)pyridin-2-yl)-4-(trifluoromethoxy)benzenesulfonamide (CAS 497060-26-1)
- 1-(4,5-Dichloro-1H-pyrrol-2-yl)ethanone (CAS 1254110-85-4)
- 3-(propan-2-yl)-1,2-dihydropyrazin-2-one (CAS 25680-59-5)
- Ethyl isopropylalaninate (CAS 67309-81-3)
- Ethyl 2-(cyclopropylamino)-4-methylpyrimidine-5-carboxylate (CAS 1379811-61-6)
- 1,4-Dimethyl-1,2,3,4-tetrahydroquinoxalin-6-ol (CAS 76154-43-3)
- 3-(4-(3,3,3-Triphenylpropyl)piperazin-1-yl)pyridazine (CAS 55921-70-5)
- 4-Chloro-2-((propylamino)methyl)phenol (CAS 1017026-04-8)
- Terbufos-Sulfone (CAS 56070-16-7)
- 1-(3,5-Difluoro-4-isobutoxyphenyl)-2,2,2-trifluoroethan-1-one (CAS 1443350-69-3)
- Glucagon (1-29) (CAS 16941-32-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com