4-(Bromomethyl)-2,2-difluoro-2h-1,3-benzodioxole CAS 72769-05-2
| CAS No. | 72769-05-2 |
| Molecular Formula | C8H5BrF2O2 |
| Molecular Weight | 251.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Bromomethyl)-2,2-difluoro-2h-1,3-benzodioxole.
4-(Bromomethyl)-2,2-difluoro-2h-1,3-benzodioxole (CAS 72769-05-2), molecular formula C8H5BrF2O2 and molecular weight 251.02 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Bromomethyl)-2,2-difluoro-2h-1,3-benzodioxole (C8H5BrF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Bromomethyl)-2,2-difluoro-2h-1,3-benzodioxole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrF2O2 |
| Molecular Weight | 251.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F/Br-containing |
Related Bromomethyl Standards
- 5-(Bromomethyl)-2-ethoxy-1,3-difluorobenzene (CAS 1017779-38-2)
- 2-(Bromomethyl)-1-(difluoromethoxy)-4-methylbenzene (CAS 1342768-08-4)
- 1-(Bromomethyl)-2,3-difluoro-5-methoxy-4-methylbenzene (CAS 1706430-78-5)
- 4-(Bromomethyl)-6-(difluoromethyl)-3-methylpyridin-2-amine (CAS 1803686-78-3)
- 3-(Bromomethyl)-5-(difluoromethyl)-6-methylpyridin-2-amine (CAS 1804686-54-1)
- 5-(Bromomethyl)-3-(difluoromethyl)-6-methylpyridin-2-amine (CAS 1805012-22-9)
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- 5-(Bromomethyl)-3-(difluoromethyl)-4-methylpyridin-2-amine (CAS 1806893-91-3)
Recommended Standards
- 3-Bromo-5-(difluoromethyl)benzoic acid (CAS 2169047-47-4)
- 4-Bromo-2,5-difluorophenylacetic Acid (CAS 871035-64-2)
- 3-Bromo-2-(difluoromethyl)benzoic acid (CAS 944268-51-3)
- 4-Bromo-3-(difluoromethyl)benzoic acid (CAS 2167386-60-7)
- 2-mercapto-3-[3-(pyrrolidin-1-ylsulfonyl)phenyl]quinazolin-4(3H)-one (CAS 730976-45-1)
- 3-(3-Methoxy-4-nitrophenyl)-5-methyl-1H-1,2,4-triazole (CAS 648917-49-1)
- (4-Ethyl-1,2,3-thiadiazol-5-yl)methanamine (CAS 1520862-09-2)
- 5-fluoro-7-methyl-2,3-dihydro-1$l^{6},2-benzothiazole-1,1,3-trione (CAS 1384428-65-2)
- 2-(Aminomethyl)-3-bromo-4-(difluoromethyl)pyridine-5-methanol (CAS 1806923-51-2)
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