(2S,4S)-4-(Fluoromethyl)-5-oxopyrrolidine-2-carboxylic acid CAS 728034-36-4
| CAS No. | 728034-36-4 |
| Molecular Formula | C6H8FNO3 |
| Molecular Weight | 161.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (2S,4S)-4-(Fluoromethyl)-5-oxopyrrolidine-2-carboxylic acid (C6H8FNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
(2S,4S)-4-(Fluoromethyl)-5-oxopyrrolidine-2-carboxylic acid (CAS 728034-36-4) is a high-purity analytical reference standard with the molecular formula C6H8FNO3 and a molecular weight of 161.13 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8FNO3 |
| Molecular Weight | 161.13 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (2R,3S)-Methyl 3-fluoro-5-oxopyrrolidine-2-carboxylate (CAS 97315-83-8)
- (2S,4S)-Methyl 4-fluoro-5-oxopyrrolidine-2-carboxylate (CAS 95048-76-3)
- (2R,3R)-Methyl 3-fluoro-5-oxopyrrolidine-2-carboxylate (CAS 97315-82-7)
- 4-Amino-5-fluoro-6-methoxy-5,6-dihydropyrimidin-2(1H)-one (CAS 272781-94-9)
- [4'-(Methylsulfanyl)[1,1'-biphenyl]-4-yl] acetonitrile (CAS 893734-20-8)
- Ethyl 6-bromo-4-nitro-3-pyridinecarboxylate (CAS 1807273-58-0)
- 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine (S)-5-oxopyrrolidine-2-carboxylate (CAS 93963-66-7)
- 1-Amino-2-methylpropane-2-selenol (CAS 801213-58-1)
- 3-(4-(4-Chloro-2-(trifluoromethyl)phenyl)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one (CAS 1219454-01-9)
- (S)-6-chloro-2-(pyrrolidin-2-yl)-3-(trifluoromethyl)phenol (CAS 1213934-25-8)
- (S)-2-(((Benzyloxy)carbonyl)amino)-3-(4-cyanophenyl)propanoic acid (CAS 131669-07-3)
- 2,4-Dichloro-D-phenylalanine (CAS 114872-98-9)
- N-(2,4,5-trichlorophenyl)propionamide (CAS 26320-49-0)
- 263251-78-1 NMG938VJ6T D-3 Tavilermide [USAN:INN] UNII-NMG938VJ6T MIM-D3 MIM-D 3 D 3 (peptide) Tavilermide (CAS 263251-78-1)
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