Acesulfame Potassium EP Impurity B CAS 72827-08-8
| CAS No. | 72827-08-8 |
| Molecular Formula | C4H4ClNO4S |
| Molecular Weight | 197.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Acesulfame Potassium EP Impurity B (C4H4ClNO4S) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Acesulfame Potassium EP Impurity B (CAS 72827-08-8, C4H4ClNO4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H4ClNO4S |
| Molecular Weight | 197.60 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Acesulfame Standards
- Acesulfame impurity 4 (CAS 459454-05-8)
- Acesulfame potassium EP Impurity A (CAS 5977-14-0)
- Acesulfame impurity 3 (CAS 1314966-13-6)
- Acesulfame Aspartame Salt (CAS 106372-55-8)
- Acesulfame calcium (CAS 54054-83-0)
- Acesulfame Potassium (CAS 55589-62-3)
- Acesulfame-d4 Potassium Salt (CAS 1623054-53-4)
- Acesulfame Potassium,Aspartame In Drink (CAS CATO-CCRM104022)
Recommended Standards
- 6-Chloro-7-fluoroquinazolin-2-amine (CAS 2763595-61-3)
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- 3-Chloro-7-fluoroquinoxalin-2-amine (CAS 888480-65-7)
- 2-Chloro-1-(4,4-difluoro-1-piperidinyl)ethanone (CAS 619254-09-0)
- Nilotinib Impurity 40 (CAS 859026-97-4)
- Decitabine Impurity 48 (CAS CATO-C4X-113748)
- Gadobutrol Impurity 104 4HCl (CAS 112193-75-6（free base）)
- Diisobutyl phenylboronate (CAS 59024-15-6)
- 7-Hydroxy-1,3-dimethylindolin-2-one (CAS 412283-83-1)
- 1-(Tert-butoxycarbonyl)-4-methoxy-2,2-dimethylpiperidine-4-carboxylic acid (CAS 2279714-58-6)
- Potassium (1-(tert-butoxycarbonyl)-1H-pyrrol-2-yl)trifluoroborate (CAS 1111732-78-5)
- 5-Chloro-4-methyl-2-(trifluoromethyl)pyridine (CAS 1260783-20-7)
- N-(Pyrimidin-2-yl)acetamide (CAS 13053-88-8)
- Galanin-Like Peptide (human) trifluoroacetate salt (CAS 245114-99-2)
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