2-(Difluoromethoxy)-3-methoxybenzoic acid CAS 730951-44-7
| CAS No. | 730951-44-7 |
| Molecular Formula | C9H8F2O4 |
| Molecular Weight | 218.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Difluoromethoxy)-3-methoxybenzoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(Difluoromethoxy)-3-methoxybenzoic acid (CAS 730951-44-7), molecular formula C9H8F2O4 and molecular weight 218.15 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-(Difluoromethoxy)-3-methoxybenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 218.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(Difluoromethoxy)-3-methoxybenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8F2O4 |
| Molecular Weight | 218.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- Methyl 4-(difluoromethoxy)-3-hydroxybenzoate (CAS 1159429-52-3)
- 2-(4-(Difluoromethoxy)phenyl)-2-hydroxyacetic acid (CAS 1214377-14-6)
- 2-(2-(Difluoromethoxy)phenyl)-2-hydroxyacetic acid (CAS 1214384-68-5)
- 2-(difluoromethoxy)-4-methoxybenzoic acid (CAS 1293108-58-3)
- 4-(Difluoromethoxy)-3-hydroxyphenylacetic Acid (CAS 1312884-10-8)
- 4-(Difluoromethoxy)-3-methoxybenzoic acid (CAS 162401-59-4)
- 3-Difluoromethoxy-4-methoxybenzoic Acid (CAS 162401-65-2)
- 1-(4-(Difluoromethoxy)-2-fluorophenyl)propan-1-one (CAS 1261453-51-3)
Recommended Standards
- 2-(1,1,2,2-Tetrafluoroethyl)-1H-benzo[d]imidazole (CAS 61532-00-1)
- 2,3-Difluoro-4,5-dimethoxybenzoic acid (CAS 2379322-78-6)
- 2,3-Difluoro-6-(methoxymethoxy)benzoic acid (CAS 2179038-37-8)
- 2,5-Difluoro-3-(methoxymethoxy)benzoic acid (CAS 938181-83-0)
- 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride (CAS 840489-25-0)
- (6-(Azetidin-1-ylsulfonyl)pyridin-3-yl)methanol (CAS 1334494-94-8)
- 4-(2-Aminoacetyl)piperazine-1-carboxamide hydrochloride (CAS 1049744-31-1)
- 3-(2-Biphenyl)-2-chloro-1-propene (CAS 951889-99-9)
- ((2-(2-Bromoethoxy)ethoxy)methyl)benzene (CAS 125562-32-5)
- 7-Nitro-1,3-dihydrobenzo[c]isothiazole 2,2-Dioxide (CAS 111248-95-4)
- 5-ethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1248969-30-3)
- Benzyl Azetidin-3-ylcarbamate (CAS 914348-04-2)
- Benzyl (1-(oxetan-3-yl)piperidin-4-yl)carbamate (CAS 1349716-55-7)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
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