5-Methyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide CAS 738531-66-3
| CAS No. | 738531-66-3 |
| Molecular Formula | C8H6N4O4S |
| Molecular Weight | 254.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Methyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide (CAS 738531-66-3) is a high-purity analytical reference standard with the molecular formula C8H6N4O4S and a molecular weight of 254.22 g/mol.
5-Methyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide (C8H6N4O4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6N4O4S |
| Molecular Weight | 254.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Recommended Standards
- 5-methoxy-4-nitrobenzo[d]thiazole-2-carboxylic acid (CAS 886745-59-1)
- 5-Nitroquinoline-8-sulfonic acid (CAS 854694-82-9)
- 4-(6-Fluoropyridin-3-yl)-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile (CAS 2222654-09-1)
- N-(2,4-Dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)methanesulfonamide (CAS 885269-56-7)
- 2-fluoro-3-hydroxy-5-methylcyclohex-2-en-1-one (CAS 2231677-08-8)
- 5-(3-Methylisoxazol-5-yl)pentan-1-ol (CAS 118276-21-4)
- N-Methylbenzo[d]thiazol-2-amine (CAS 16954-69-1)
- 2-Oxo-N-(2-propionyl-1,2,3,4-tetrahydroisoquinolin-7-yl)imidazolidine-1-carboxamide (CAS 1797792-43-8)
- Methyl 1-(3-methoxy-3-oxopropyl)-1H-pyrazole-4-carboxylate (CAS 1174836-98-6)
- (2-Ethyl-1H-imidazol-1-yl)methanol (CAS 339363-00-7)
- 7-Chloro-4H-pyrimido[1,2-b]pyridazin-4-one (CAS 88820-50-2)
- (3S,4S)-4-Amino-3-methoxytetrahydropyran (CAS 1232064-61-7)
- Rosuvastatin EP Impurity M(Sodium Salt) (CAS 847849-66-5(free base))
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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