Tazobactam Acid Impurity 27 CAS 74189-25-6
| CAS No. | 74189-25-6 |
| Molecular Formula | C21H20BrNO3S |
| Molecular Weight | 446.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tazobactam Acid Impurity 27 (CAS 74189-25-6, C21H20BrNO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tazobactam Acid Impurity 27 (C21H20BrNO3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20BrNO3S |
| Molecular Weight | 446.36 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Tazobactam Standards
- Tazobactam Impurity 36 (CAS CATO-C4X-120536)
- Tazobactam Impurity 7 (CAS CATO-C4X-12057)
- Tazobactam Impurity 8 (CAS CATO-C4X-12058)
- Tazobactam Impurity 24 (CAS 89051-49-0)
- Tazobactam Impurity 12 (CAS CATO-C4X-120512)
- Tazobactam Impurity 37 (CAS CATO-C4X-120537)
- Tazobactam Impurity 34 (CAS CATO-C4X-120534)
- Tazobactam Impurity 35 (CAS 125949-72-6)
Recommended Standards
- Methyl-2-deoxy-3,5-di-o-p-nitrobenzoyl-d-ribofuranoside (CAS 62279-73-6)
- Folic Acid-13C5 (CAS 1207282-75-4)
- Genistein 4'-β-D-Glucuronide (CAS 245084-07-5)
- Baicalin (CAS 21967-41-9)
- Ioversol impurity 33 (CAS CATO-C4X-209133)
- Rosuvastatin Impurity 96 (CAS 521974-00-5)
- Pirarubicin Impurity 2 (CAS CATO-C4X-24682)
- Perfluorophenyl isonicotinate (CAS 360574-34-1)
- Methyl (3R)-2-acetyl-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate (CAS 1217649-95-0)
- N-[(3,5-dimethoxyphenyl)methylidene]hydroxylamine (CAS 34967-25-4)
- Tofacitinib Impurity 204 (CAS CATO-C4X-1079204)
- 5-Acetyl-2-(2-benzoyl-4-methoxyphenoxy) pyridine (CAS 1809098-74-5)
- Baccharin (CAS 61251-97-6)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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