2-Cyano-3-[1-(2,5-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid CAS 743440-35-9
| CAS No. | 743440-35-9 |
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Cyano-3-[1-(2,5-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid.
2-Cyano-3-[1-(2,5-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid (CAS 743440-35-9), molecular formula C16H12Cl2N2O2 and molecular weight 335.18 g/mol, is a CATO reference standard with documented purity and traceability.
2-Cyano-3-[1-(2,5-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid (C16H12Cl2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Cyano-3-[1-(2,5-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2N2O2 |
| Molecular Weight | 335.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 2-Cyano-3-[1-(2,3-dichlorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid (CAS 743440-58-6)
- 5-((5-Cyano-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-N-(2-methoxyethyl)-4,5-dihydroisoxazole-3-carboxamide (CAS 338399-99-8)
- 2-[5-cyano-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]ethyl 4-methylbenzenesulfonate (CAS 106271-61-8)
- 1-(4-Cyano-phenyl)-5-(4-methylsulfanyl-phenyl)-1H-pyrazole-3-carboxylic acid (CAS 151507-00-5)
- 4-Cyano-N-(4-(4-methoxyphenyl)thiazol-2-yl)benzamide (CAS 313662-31-6)
- Ethyl 5-cyano-2-phenyl-6-(piperidin-1-yl)nicotinate (CAS 477866-04-9)
- 3-Cyano-4-(3-methyl-4-(methylthio)phenoxy)benzenesulfonamide (CAS 1204513-72-3)
- 2-((1-Cyano-1-cyclopropylethyl)amino)-2-oxoethyl 4-oxo-4-(thiophen-2-yl)butanoate (CAS 923188-05-0)
Recommended Standards
- 3-(2,4- Dichlorophenyl)-7-ethoxycoumarin (CAS 263365-41-9)
- 2-Amino-4-(2,4-dichlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (CAS 315245-07-9)
- 3-(4-((4-Chlorobenzyl)oxy)phenyl)-5-(chloromethyl)-1,2,4-oxadiazole (CAS 286841-02-9)
- 2,3-Dichloro-1,4-bis(methylamino)anthracene-9,10-dione (CAS 72918-26-4)
- 5-Benzyl-2-oxa-5-aza-bicyclo[2.2.2]octane-4-carboxylic acid ethyl ester (CAS 2379651-38-2)
- N-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)isobutyramide (CAS 2246875-71-6)
- 2-Methyl-5-(pentafluoro-λ6-sulfanyl)benzoic acid (CAS 623943-54-4)
- Methyl 3-amino-6-(trifluoromethyl)pyrazine-2-carboxylate (CAS 1744-13-4)
- Palonosetron Impurity 38 (CAS CATO-C4X-110538)
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- 2-Cyclopropyl-5-fluoropyridine (CAS 1803591-15-2)
- 3-((4-(Thiophen-2-yl)thiazol-2-yl)amino)benzoic acid (CAS 103755-01-7)
- 2-(1H-benzimidazol-2-yl)-1-(2-furyl)ethanone hydrochloride (CAS 1177272-41-1)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
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