(2E)-4-(4-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)-4-oxobut-2-enoic acid CAS 743445-12-7
| CAS No. | 743445-12-7 |
| Molecular Formula | C15H14ClF3N2O5S |
| Molecular Weight | 426.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(2E)-4-(4-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)-4-oxobut-2-enoic acid (CAS 743445-12-7), molecular formula C15H14ClF3N2O5S and molecular weight 426.80 g/mol, is a CATO reference standard with documented purity and traceability.
(2E)-4-(4-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)-4-oxobut-2-enoic acid (C15H14ClF3N2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), (2E)-4-(4-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)-4-oxobut-2-enoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14ClF3N2O5S |
| Molecular Weight | 426.80 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 5-Chloro-6-methoxy-2-methylbenzo[d]thiazole (CAS 188065-59-0)
- (6-(Cyclopropylamino)-5-methylpyridin-3-yl)(phenyl)methanone (CAS 1355202-60-6)
- 2-Oxo-N-phenylbenzo[d]oxazole-3(2H)-carboxamide (CAS 7039-00-1)
- 3-((Tert-butoxycarbonyl)amino)-4-cyclohexylbutanoic acid (CAS 886503-06-6)
- 6-Amino-4-bromo-5-(difluoromethyl)nicotinonitrile (CAS 1805256-59-0)
- (2E)-4-[(3-Chlorophenyl)amino]-4-oxobut-2-enoic acid (CAS 18196-80-0)
- 4-Benzyloxynaphthalene-1-carboxaldehyde (CAS 213455-52-8)
- 2-(1-Methyl-1h-pyrazol-4-yl)cyclopentane-1-carboxylic acid (CAS 1515243-89-6)
- N1,N3-Di(pyridin-4-yl)isophthalamide (CAS 82292-44-2)
- Amyloid Precursor Frameshift Mutant C-Terminal Peptide trifluoroacetate salt (CAS 189125-14-2)
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