N-Nitroso Carbamazepine EP Impurity E (N-Nitroso Clomipramine HCl EP Impurity E) CAS 7458-08-4
| CAS No. | 7458-08-4 |
| Molecular Formula | C14H12N2O |
| Molecular Weight | 224.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-Nitroso Carbamazepine EP Impurity E (N-Nitroso Clomipramine HCl EP Impurity E) (C14H12N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, N-Nitroso Carbamazepine EP Impurity E (N-Nitroso Clomipramine HCl EP Impurity E) (CAS 7458-08-4, C14H12N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures N-Nitroso Carbamazepine EP Impurity E (N-Nitroso Clomipramine HCl EP Impurity E) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H12N2O |
| Molecular Weight | 224.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 2 |
Related N Standards
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- N-Nitroso Lorcaserin (CAS 2518136-84-8)
- 4-(methyl(Nitroso)amino)-3-nitrobenzoic acid (CAS CATO-C3D-26217)
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- N-nitroso-meglumine 15N (CAS CATO-LCAD304328)
- 3-Nitroso-2-phenylimidazo[1,2-a]pyridine (CAS 3672-37-5)
- N-Nitroso Trazodone EP Impurity L (CAS 2219339-13-4)
Recommended Standards
- N-Methyl-6-phenylimidazo[1,2-a]pyrazin-8-amine (CAS 787591-86-0)
- Tert-butyl ((6-oxo-1,6-dihydropyridin-2-yl)methyl)carbamate (CAS 2283041-55-2)
- N-Methyl-5-phenylimidazo[1,2-a]pyrazin-8-amine (CAS 787591-79-1)
- tert-Butyl (2-methoxypyridin-4-yl)carbamate (CAS 849353-31-7)
- Paricalcitol Impurity 37 (CAS 1154606-20-8)
- Sildenafil Impurity 260 (CAS CATO-C4X-1128260)
- Clindamycin Phosphas EP Impurity D (CAS 54887-30-8)
- 4-((Pyridin-2-ylmethyl)amino)quinazoline-6-carbaldehyde (CAS 648449-13-2)
- trans-3-methoxytetrahydropyran-4-amine;hydrochloride (CAS 1778734-55-6)
- (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide (CAS 54130-36-8)
- 2,2-Dimethyl-3-(2-methyl-1-propenyl)-cyclopropanecarbonylchloride (CAS 14297-81-5)
- 2,2,2-Trifluoro-N-(2-Methoxyphenethyl)Acetamide (CAS 304458-32-0)
- 3-PhenylÂpropionic acid anhydride (CAS 15781-96-1)
- His-Aib-Semaglutide (CAS CATO-C4X-2226220)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com