8-Amino-2-chloroquinoline CAS 7461-11-2
| CAS No. | 7461-11-2 |
| Molecular Formula | C9H7ClN2 |
| Molecular Weight | 178.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Amino-2-chloroquinoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Amino-2-chloroquinoline (CAS 7461-11-2) is a high-purity analytical reference standard with the molecular formula C9H7ClN2 and a molecular weight of 178.62 g/mol.
8-Amino-2-chloroquinoline (C9H7ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Amino-2-chloroquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7ClN2 |
| Molecular Weight | 178.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 4-amino-2-chloropyridine-3-carboxylic acid (CAS 1018678-38-0)
- 4-amino-6-chloropyridine-3-carboxylic acid (CAS 1060811-65-5)
- 3-Amino-3-(4-chlorophenyl)prop-2-enenitrile (CAS 107840-43-7)
- 6-Amino-4-chloroquinoline (CAS 1085192-91-1)
- 3-amino-6-chloro-pyrazine-2-carboxamide (CAS 1125-56-0)
- 3-Amino-2-chloroquinoline (CAS 116632-54-3)
- 7-Amino-3-chloroquinoline (CAS 1354222-11-9)
- 5-Amino-4-chloroquinoline (CAS 1824318-74-2)
Recommended Standards
- 7-Chloroquinolin-6-amine (CAS 6312-75-0)
- 8-Amino-7-chloroquinoline (CAS 6338-98-3)
- 7-Chloroquinolin-5-amine (CAS 2089651-39-6)
- 8-Chloro-2-methyl-1,5-naphthyridine (CAS 911389-21-4)
- 2-Bromo-3-chloro-5-nitrobenzonitrile (CAS 1426805-54-0)
- 2-(1-Isopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)acetonitrile (CAS 1402445-78-6)
- (2R,4R,6S)-2,4,6-trimethylpiperidine hydrochloride (CAS 69682-14-0)
- 3-(2,2,2-Trifluoroethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine (CAS 1393563-34-2)
- Methyl 6-methoxy-3-(1H-tetrazol-1-yl)-1H-indole-2-carboxylate (CAS 924858-77-5)
- HO-Ste-γGlu-AEEA-AEEA-AEEA-OH (CAS CATO-C4X-2226285)
- Pcb No. 202 (CAS 2136-99-4)
- 1-(2-Amino-5-(piperidin-1-yl)phenyl)ethan-1-one (CAS 60283-14-9)
- 4-Chloro-6-{4-[5-(furan-2-yl)-1H-pyrazol-3-yl]piperidin-1-yl}pyrimidin-2-amine (CAS 1026080-38-5)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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