1H-Pyrazole-3,5-dicarbonyl chloride CAS 74621-40-2
| CAS No. | 74621-40-2 |
| Molecular Formula | C5H2Cl2N2O2 |
| Molecular Weight | 192.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1H-Pyrazole-3,5-dicarbonyl chloride (CAS 74621-40-2) is a high-purity analytical reference standard with the molecular formula C5H2Cl2N2O2 and a molecular weight of 192.99 g/mol.
1H-Pyrazole-3,5-dicarbonyl chloride (C5H2Cl2N2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2Cl2N2O2 |
| Molecular Weight | 192.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related H Standards
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- 40545-65-1 Pyrazole, 3-amino-4-(p-chlorophenyl)- 3-Amino-4(p-chlorophenyl)-pyrazole BRN 0641017 USAF EL-83 (CAS 40545-65-1)
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Recommended Standards
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- 2,4-Dichloro-3-nitropyridine (CAS 5975-12-2)
- 4-AMino-3-iodo-5-trifluoromethyl-benzonitrile (CAS 62584-29-6)
- Methyl (4-hydroxy-1,2-dihydropyrimido-[1,2-a]benzimidazol-2-yl)acetate (CAS 1306739-45-6)
- 1-((4-Nitrophenoxy)methyl)-1H-pyrazole-3-carboxylic acid (CAS 1006954-05-7)
- Tadalafil-13C2,d3 (CAS CATO-C4X-108754)
- 3-((4-Amino-6-oxo-1,6-dihydropyrimidin-2-yl)thio)propanoic acid (CAS 63916-09-6)
- Asebogenin (CAS 520-42-3)
- 4-[(4-Fluorophenyl)sulfanyl]-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine (CAS 303988-10-5)
- Aliskiren D6 (CAS 1246815-96-2)
- 2-(Chloromethyl)-3-cyano-6-(difluoromethyl)-4-methoxypyridine (CAS 1806956-98-8)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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