5-(4-Fluorophenyl)-4-(pyridin-3-yl)-1H-imidazole-2-thiol CAS 74767-75-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Fluorophenyl)-4-(pyridin-3-yl)-1H-imidazole-2-thiol.

5-(4-Fluorophenyl)-4-(pyridin-3-yl)-1H-imidazole-2-thiol (CAS 74767-75-2) is a high-purity analytical reference standard with the molecular formula C14H10FN3S and a molecular weight of 271.31 g/mol.

The molecular framework of 5-(4-Fluorophenyl)-4-(pyridin-3-yl)-1H-imidazole-2-thiol (C14H10FN3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Why CATO?

• ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
• 130,000+ catalog items in stock, COA supplied with every batch
• Worldwide shipping with full export documentation (HS code guidance available)
• Technical support: +86 18665070610 / Nicole.chen@cato-chem.com