5-Chloro-2-methylpyrimidine-4-carboxylic acid CAS 74840-47-4
| CAS No. | 74840-47-4 |
| Molecular Formula | C6H5ClN2O2 |
| Molecular Weight | 172.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 172.57 g/mol gives 5-Chloro-2-methylpyrimidine-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Chloro-2-methylpyrimidine-4-carboxylic acid (CAS 74840-47-4) is a high-purity analytical reference standard with the molecular formula C6H5ClN2O2 and a molecular weight of 172.57 g/mol.
The molecular framework of 5-Chloro-2-methylpyrimidine-4-carboxylic acid (C6H5ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-Chloro-2-methylpyrimidine-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5ClN2O2 |
| Molecular Weight | 172.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-5-methyl-2-nitropyridine (CAS 1210909-07-1)
- 6-Chloro-3-methyl-2-nitropyridine (CAS 1211516-41-4)
- 6-Chloro-5-methyl-3-pyridazinecarboxylic acid (CAS 1211516-60-7)
- 6-Chloro-N-hydroxypyridine-2-carboxamide (CAS 125309-38-8)
- Methyl 5-chloro-3-pyridazinecarboxylate (CAS 1256786-31-8)
- 6-Chloro-N-hydroxynicotinamide (CAS 1263094-64-9)
- 5-Chloro-N-hydroxypicolinamide (CAS 1289026-43-2)
- 6-Chloro-2-methylpyrimidine-4-carboxylic acid (CAS 136518-06-4)
Recommended Standards
- 5-Chloro-2,3-dihydroxybenzaldehyde (CAS 73275-96-4)
- 5-Chloro-3-methoxypyrazine-2-carbaldehyde (CAS 614730-18-6)
- 5-Chloro-1-methyl-6-oxo-1,6-dihydropyridazine-4-carbaldehyde (CAS 2822540-23-6)
- 5-Chloro-m-salicylic Acid (CAS 53984-36-4)
- 1-Pyridin-3-Yl-Piperazine Dihydrochloride (CAS 470441-67-9)
- 5-(Oxetan-3-yl)pyridin-2-amine (CAS 2222934-17-8)
- 2-Cyano-N-(2,4-dimethoxyphenyl)acetamide (CAS 133550-46-6)
- 5-Fluoro-2-n-propoxybenzoic acid (CAS 127980-13-6)
- 2-(3-(((Cyclopropylmethyl)amino)methyl)piperidin-1-yl)ethanamine (CAS 1353953-86-2)
- 2-(4-Bromonaphthalen-1-yl)-1,10-phenanthroline (CAS 1853997-27-9)
- 2-((5-Nitropyridin-2(1H)-ylidene)amino)ethan-1-ol (CAS 25948-12-3)
- Desvenlafaxine Succinate (CAS 386750-22-7)
- Flurbiprofen Impurity 20 (CAS CATO-C4X-144420)
- Tirzepatide Impurity 58 (CAS CATO-C4X-324058)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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