Ethyl 2-(3-Chloro-2-nitrophenyl)acetate CAS 74864-49-6
| CAS No. | 74864-49-6 |
| Molecular Formula | C10H10ClNO4 |
| Molecular Weight | 243.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 2-(3-Chloro-2-nitrophenyl)acetate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 2-(3-Chloro-2-nitrophenyl)acetate (CAS 74864-49-6) is a high-purity analytical reference standard with the molecular formula C10H10ClNO4 and a molecular weight of 243.64 g/mol.
Ethyl 2-(3-Chloro-2-nitrophenyl)acetate (C10H10ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 2-(3-Chloro-2-nitrophenyl)acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10ClNO4 |
| Molecular Weight | 243.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 2-Chloro-1-(3-nitrophenyl)ethyl acetate (CAS 103854-77-9)
- Ethyl 2-(4-Chloro-2-nitrophenyl)acetate (CAS 108274-38-0)
- Ethyl 3-chloro-4-nitrophenylacetate (CAS 1093222-12-8)
- 4-Chloro-6-(difluoromethoxy)-2-methylquinoline (CAS 1156276-49-1)
- 2-Chloro-4-((ethoxycarbonyl)amino)benzoic acid (CAS 1249754-47-9)
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- 3-(4-Chloro-3-formyl-6-methyl-2-oxopyridin-1(2H)-yl)propanoic acid (CAS 1282130-51-1)
Recommended Standards
- Dimethyl 2-amino-5-chloroterephthalate (CAS 32888-87-2)
- Ethyl 2-(4-chloro-3-nitrophenyl)acetate (CAS 745053-53-6)
- Benzenesulfonic acid, 3-amino-5-chloro-4-methyl-, sodium salt (1:1) (CAS 91889-79-1)
- Methyl 2-(4-chloro-3-nitrophenyl)propanoate (CAS 848849-59-2)
- (4-Methyl-2-(pyrazin-2-yl)thiazol-5-yl)methanol (CAS 352018-94-1)
- 2-(Furan-2-ylmethyl)octanoate (CAS 39252-03-4)
- 1-(4-Fluorophenyl)-N-((1-(2-phenoxyacetyl)piperidin-4-yl)methyl)cyclopropane-1-carboxamide (CAS 1286733-12-7)
- (8-Methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine hydrochloride (CAS 1341040-31-0)
- (S)-Ethyl 4-amino-2,2-difluorodecanoate hydrochloride (CAS 1363408-59-6)
- Ornidazole Impurity 27 (CAS 33543-81-6)
- 6-Fluoro-2-morpholinonicotinic acid (CAS 2070856-05-0)
- Daprodustat Impurity 22 (CAS CATO-C4X-240722)
- 2-AZetidin-3-yl-6-methylpyridin-4-ol bis(trifluoroacetate) (CAS 2108457-85-6)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
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